Intracellular Signaling
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.
Intracellular Signaling Products Targets
- Cdc25 Phosphatase (2)
- STAT (10)
- PI 3-kinase (22)
- JAK (10)
- PFKFB3 (3)
- Hexokinases (1)
- Protein Kinase G (3)
- NFKB and IKB (30)
- Others (3)
- Cyclooxygenase (24)
- IRAK (1)
- PORCN (4)
- beta-catenin (13)
- PPARγ (16)
- PPARδ (5)
- PPARα (7)
- Inositol Phosphatase (3)
- MYC (1)
- Sphingosine Kinase (2)
- RSK (4)
- Protein Kinase D (3)
- Polo-like Kinase (5)
- Pim Kinase (4)
- PERK (2)
- Phosphoinositide-dependent Kinase 1 (5)
- P21-activated Kinases (2)
- Myosin Light Chain Kinase (4)
- mTOR (14)
- Monopolar Spindle 1 Kinase (2)
- Mnk (2)
- MK2 (2)
- MEK (9)
- LIMK (3)
- Focal Adhesion Kinase (4)
- DNA-Dependent Protein Kinase (6)
- Diacylglycerol Kinase (2)
- Death-Associated Protein Kinase (1)
- Checkpoint Kinase (3)
- Casein Kinase 2 (3)
- Casein Kinase 1 (7)
- Bruton's Tyrosine Kinase (3)
- ATM and ATR Kinase (3)
- Akt (Protein Kinase B) (11)
- Adeonsine Kinase (2)
- Abl Kinase (9)
- Hsp90 (10)
- Hsp70 (4)
- Protein Kinase A (9)
- Protein Kinase C (29)
- Calmodulin-Dependent Kinase (8)
- LRRK2 (4)
- ERK (6)
- DYRK (3)
- Estrogen and Related Receptor (33)
- Tankyrase (5)
- ITK (2)
- ASK1 (2)
- Syk Kinase (4)
- Src Kinase (21)
- Raf Kinase (7)
- IαB Kinase (6)
- p38 MAPK (16)
- Janus N-terminal Kinase (12)
- Androgen Receptor (11)
- Glycogen Synthase Kinase 3 (20)
- AMPK (7)
- Rho-Kinases (9)
- AP-1 (2)
- SREBP (2)
- NUAK (2)
- Telomerase (3)
- Retinoid X Receptor (13)
- Retinoic Acid Receptor (22)
- Proteasome (5)
- Phospholipase (16)
- Lipase (4)
- G Protein (Small) (23)
- Hedgehog Signaling (15)
- DNA Topoisomerase (12)
- DNA, RNA and Protein Synthesis (46)
- Protein Tyrosine Phosphatases (5)
- Protein serine and threonine phosphatase (16)
- Histone Deacetylase (19)
- Aurora Kinase (9)
- Cyclin-Dependent Protein Kinase (21)
Products for Intracellular Signaling - Page 33
- Cat.No. Product Name Information/Activity
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BCC2177
SNS-314 Mesylate
SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively.
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BCC2418
TC-A 2317 hydrochloride
Potent, selective Aurora kinase A inhibitor
-
BCC2182
Aurora A Inhibitor I
Potent and selective Aurora kinase A inhibitor,Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B.
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BCC2167
VX-680 (MK-0457,Tozasertib)
Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.
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BCC2169
ZM 447439
ZM-447439 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively.
-
BCN2483
Ginkgolic acid C15:0
Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively.
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BCC4100
PCI 29732
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
-
BCC6268
PF 06465469
PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM.
-
BCC7051
(-)-Terreic acid
Selective inhibitor of BTK
-
BCC6203
A 484954
A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM.


