Intracellular Signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.

Intracellular Signaling Products Targets

Products for Intracellular Signaling - Page 66

  1. Cat.No. Product Name Information/Activity
  2. BCC3663 SB 203580 SB 203580 (RWJ 64809) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. SB 203580 does not disrupt JNK activity and is an autophagy and mitophagy activator. SB 203580 chemical structure
  3. BCC4293 SB 203580 hydrochloride SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. SB 203580 hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. SB 203580 hydrochloride is an autophagy and mitophagy activator. SB 203580 hydrochloride chemical structure
  4. BCC1923 SB 239063 SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC50 of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD. SB 239063 chemical structure
  5. BCC5615 SB 706504 911110-38-8 SB 706504 chemical structure
  6. BCC7236 SKF 86002 dihydrochloride 116339-68-5 SKF 86002 dihydrochloride chemical structure
  7. BCC7731 SX 011 309913-42-6 SX 011 chemical structure
  8. BCC3967 1-O-galloyl-2-O-cinnamoyl-beta-d-glucose 1-O-galloyl-2-O-cinnamoyl-beta-d-glucose chemical structure
  9. BCC3966 VX-745 Neflamapimod (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM. Neflamapimod (VX-745) possesses anti-inflammatory activity. VX-745 chemical structure
  10. BCC6225 HI TOPK 032 HI-TOPK-032 is a potent and specific TOPK inhibitor. HI TOPK 032 chemical structure

Items 651 to 659 of 659 total