Intracellular Signaling
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.
Intracellular Signaling Products Targets
- Cdc25 Phosphatase (2)
- STAT (10)
- PI 3-kinase (22)
- JAK (10)
- PFKFB3 (3)
- Hexokinases (1)
- Protein Kinase G (3)
- NFKB and IKB (30)
- Others (3)
- Cyclooxygenase (24)
- IRAK (1)
- PORCN (4)
- beta-catenin (13)
- PPARγ (16)
- PPARδ (5)
- PPARα (7)
- Inositol Phosphatase (3)
- MYC (1)
- Sphingosine Kinase (2)
- RSK (4)
- Protein Kinase D (3)
- Polo-like Kinase (5)
- Pim Kinase (4)
- PERK (2)
- Phosphoinositide-dependent Kinase 1 (5)
- P21-activated Kinases (2)
- Myosin Light Chain Kinase (4)
- mTOR (14)
- Monopolar Spindle 1 Kinase (2)
- Mnk (2)
- MK2 (2)
- MEK (9)
- LIMK (3)
- Focal Adhesion Kinase (4)
- DNA-Dependent Protein Kinase (6)
- Diacylglycerol Kinase (2)
- Death-Associated Protein Kinase (1)
- Checkpoint Kinase (3)
- Casein Kinase 2 (3)
- Casein Kinase 1 (7)
- Bruton's Tyrosine Kinase (3)
- ATM and ATR Kinase (3)
- Akt (Protein Kinase B) (11)
- Adeonsine Kinase (2)
- Abl Kinase (9)
- Hsp90 (10)
- Hsp70 (4)
- Protein Kinase A (9)
- Protein Kinase C (29)
- Calmodulin-Dependent Kinase (8)
- LRRK2 (4)
- ERK (6)
- DYRK (3)
- Estrogen and Related Receptor (33)
- Tankyrase (5)
- ITK (2)
- ASK1 (2)
- Syk Kinase (4)
- Src Kinase (21)
- Raf Kinase (7)
- IαB Kinase (6)
- p38 MAPK (16)
- Janus N-terminal Kinase (12)
- Androgen Receptor (11)
- Glycogen Synthase Kinase 3 (20)
- AMPK (7)
- Rho-Kinases (9)
- AP-1 (2)
- SREBP (2)
- NUAK (2)
- Telomerase (3)
- Retinoid X Receptor (13)
- Retinoic Acid Receptor (22)
- Proteasome (5)
- Phospholipase (16)
- Lipase (4)
- G Protein (Small) (23)
- Hedgehog Signaling (15)
- DNA Topoisomerase (12)
- DNA, RNA and Protein Synthesis (46)
- Protein Tyrosine Phosphatases (5)
- Protein serine and threonine phosphatase (16)
- Histone Deacetylase (19)
- Aurora Kinase (9)
- Cyclin-Dependent Protein Kinase (21)
Products for Intracellular Signaling - Page 59
- Cat.No. Product Name Information/Activity
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BCC2467
BVT 948
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor which can also inhibit several cytochrome P450 (P450) isoforms and lysine methyltransferase SETD8 (KMT5A).
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BCC2468
NSC 87877
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26).
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BCC5482
SF1670
SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor.
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BCC3856
Sodium Orthovanadate
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
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BCC6184
Fatostatin A
298197-04-3
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BCC6009
PF 429242
947303-87-9
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BCC7881
CP 775146
702680-17-9
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BCC4781
Fenofibrate
Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
-
BCC7150
GW 7647
GW7647 is a potent PPARα agonist, with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively.
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BCC7084
Oleylethanolamide
Oleoylethanolamide is a high affinity endogenous PPAR-α agonist, which plays an important role in the treatment of obesity and arteriosclerosis.


