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Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Products for Neuroscience

Cat.No. Product Name Information
BCC4049 Ciproxifan maleate Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
BCC7245 ROS 234 dioxalate
BCC6003 NAD 299 hydrochloride
BCC1716 LY 344864 LY 344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
BCC7840 L 760735
BCC7435 NGB 2904
BCC1008 Endomorphin-1 Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.
BCC7330 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.
BCC5498 Firocoxib Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects.
BCC1002 Beta-Amyloid (1-11) β-amyloid (1-11) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
BCC4538 Bepotastine Besilate Bepotastine Beslilate is a orally active second-generation histamine H1 receptor antagonist. Bepotastine Beslilate has the potential for allergic rhinitis and urticaria/pruritus treatment.
BCC4466 Pramipexole 2HCl Monohydrate Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
BCC7368 LY 379268 Highly selective group II mGlu agonist
BCC6284 SIB 1553A hydrochloride SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.
BCC7975 SIB 1508Y maleate
BCC5052 LY310762 LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
BCC5065 BRL-15572 BRL-15572 2Hcl is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
BCC5702 ACPT-I
BCC6661 4-DAMP
BCN2869 Galantamine hydrobromide Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.
BCN1189 Alphitolic acid
BCC6736 HTMT dimaleate
BCC6613 (RS)-3,5-DHPG
BCC1032 Gap 26 Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
BCC4026 Loxapine Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
BCC1033 Gap 27 Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor.
BCC6983 LY 367385 LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects.
BCC4041 Parecoxib Parecoxib is a potent and selective COX-2 inhibitor.
BCC4248 Parecoxib Sodium Parecoxib Sodium (SC 69124A) is a potent and selective COX-2 inhibitor.
BCC1909 RS 127445 RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
BCC6848 SKF 38393 hydrobromide
BCC1043 Melanocyte stimulating hormone release inhibiting factor Antagonizes opioid effects in vivo. Also inhibits α-MSH release
BCC5746 UB 165 fumarate
BCC6760 7-Hydroxy-PIPAT maleate
BCC1927 SB-269970 SB269970 is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
BCC7046 (R)-3,4-DCPG
BCC7012 (S)-3,4-DCPG
BCC6217 PTAC oxalate
BCC5263 Bilastine Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.
BCC1565 Etoricoxib Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
BCC6548 DL-AP4
BCC7923 JHW 007 hydrochloride
BCC6846 3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride
BCC1818 Olcegepant Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.
BCC7705 3-Bromocytisine 3-Bromocytisine (3-Br-cytisine) is a potent nACh receptors agonist, with IC50s are 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7-nACh, respectively. 3-Bromocytisine (3-Br-cytisine) shows different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs with EC50s are 8 and 50 nM, respectively.
BCC6753 BTCP maleate
BCC4583 5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM) Desfesoterodine (PNU-200577; Desfesoterodine) is a potent and selective muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively.
BCC5774 Hemokinin 1 (mouse) Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
BCC3618 DAPT (GSI-IX) DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.
BCC5057 SB271046
BCC1924 SB 271046 hydrochloride SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
BCC4495 Sitaxentan sodium Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors.
BCC7702 PD 168568 dihydrochloride
BCC6682 W-84 dibromide
BCC5063 BMY 7378 5-HT_1A partial agonist,BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
BCC7469 TC 2559 difumarate
BCC7102 5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
BCC5967 Pemoline
BCC1114 Mianserin HCl Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
BCC8052 SB269652 SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.
BCC1928 SB-277011 SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.
BCC5975 α-Conotoxin AuIB
BCC4519 Hydroxyzine 2HCl Hydroxyzine dihydrochloride is a histamine H1-receptor antagonist.
BCC5040 Escitalopram Oxalate Escitalopram oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
BCC1902 RJR-2403 oxalate Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).
BCC4430 Ketoprofen Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.
BCC4440 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with Ki of 0.06 μM. It also inhibits COX1 with Ki of 3 μM.
BCC3795 Ipratropium Bromide Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.
BCC1329 Adoprazine Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
BCC6642 Bromocriptine mesylate Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
BCC1941 SEA0400 SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
BCC6119 NPS 2390
BCC7402 Lofepramine Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.
BCC6550 L-AP4 L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
BCC4156 Varenicline Hydrochloride Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist. Varenicline Hydrochloride is also a potent partial agonist of α6β2 nAChR in striatum of rats with a Ki value of 0.12 nM.
BCC7145 PD 102807
BCC4589 Ifenprodil Tartrate Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.
BCC6672 Dimaprit dihydrochloride
BCC5915 Bay 36-7620 Non-competitive mGlu₁ antagonist with inverse agonist activity
BCC7029 U 99194 maleate
BCC4463 Levosulpiride Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class.
BCC7851 Flupenthixol dihydrochloride Flupentixol dihydrochloride, a thioxanthene drug, is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.
BCC5671 2-CMDO
BCC4134 Mianserin Mianserin is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
BCC4580 Solifenacin succinate Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
BCC4427 Bufexamac Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent.
BCC7754 Kynurenic acid sodium salt Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.
BCC6437 LED209 LED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC.
BCC7556 (+)-Muscarine iodide
BCC7513 Ro 64-5229
BCC1390 Azaphen Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.
BCC4155 Varenicline Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment.
BCC7664 PNU 177864 hydrochloride
BCC5032 Trazodone HCl Trazodone (hydrochloride) (AF-1161) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
BCC7389 J 104129 fumarate
BCC4573 Otilonium Bromide Octylonium bromide (SP63) is an antimuscarinic used as a spasmolytic agent.
BCC4035 Frentizole Frentizole, an FDA-approved immunosuppressive drug, is a novel inhibitor of the Aβ-ABAD interaction.
BCC6490 Naproxen Sodium Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
BCC5056 SB269970 HCl SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.
BCC4954 Fosaprepitant dimeglumine salt Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.