Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Products for Neuroscience
- AChR(52)
- Histamine Receptor(89)
- Dopamine Receptor(114)
- Histamine(3)
- AChE(3)
- SSRIs(8)
- P2X7 receptor(4)
- 5-HT Receptor(238)
- Nicotinic Receptor(61)
- Amyloid β(20)
- Muscarinic Receptor(38)
- Alzheimer(3)
- COX(44)
- GluR(115)
- Neuroscience Peptides(10)
- Substance P/NK1 Receptor(21)
- P2 Receptor(2)
- BACE(3)
- Gap Junction(8)
- CGRP(3)
- DAPK(1)
- GABA Receptor(103)
- NMDA(1)
- mPEGS-1(1)
- Cat.No. Product Name Information
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BCC4049
Ciproxifan maleate
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.
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BCC7245
ROS 234 dioxalate
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BCC6003
NAD 299 hydrochloride
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BCC1716
LY 344864
LY 344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
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BCC7840
L 760735
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BCC7435
NGB 2904
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BCC1008
Endomorphin-1
Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa3 binding sites, with Ki value between 20 and 30 nM.
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BCC7330
Ro 10-5824 dihydrochloride
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.
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BCC5498
Firocoxib
Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects.
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BCC1002
Beta-Amyloid (1-11)
β-amyloid (1-11) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
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BCC4538
Bepotastine Besilate
Bepotastine Beslilate is a orally active second-generation histamine H1 receptor antagonist. Bepotastine Beslilate has the potential for allergic rhinitis and urticaria/pruritus treatment.
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BCC4466
Pramipexole 2HCl Monohydrate
Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
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BCC7368
LY 379268
Highly selective group II mGlu agonist
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BCC6284
SIB 1553A hydrochloride
SIB-1553A is an orally bioavailable nicotinic acetylcholine receptors (nAChRs) agonist, with selectivity for β4 subunit-containing nAChRs. SIB-1553A is also a selective neuronal nAChR ligand. SIB-1553A is a cognitive enhancer, and has therapeutic potential for the symptomatic treatment of Alzheimer’s disease and other cognitive disorders.
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BCC7975
SIB 1508Y maleate
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BCC5052
LY310762
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
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BCC5065
BRL-15572
BRL-15572 2Hcl is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor.
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BCC5702
ACPT-I
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BCC6661
4-DAMP
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BCN2869
Galantamine hydrobromide
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase(AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors.
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BCN1189
Alphitolic acid
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BCC6736
HTMT dimaleate
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BCC6613
(RS)-3,5-DHPG
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BCC1032
Gap 26
Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
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BCC4026
Loxapine
Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
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BCC1033
Gap 27
Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor.
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BCC6983
LY 367385
LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects.
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BCC4041
Parecoxib
Parecoxib is a potent and selective COX-2 inhibitor.
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BCC4248
Parecoxib Sodium
Parecoxib Sodium (SC 69124A) is a potent and selective COX-2 inhibitor.
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BCC1909
RS 127445
RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
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BCC6848
SKF 38393 hydrobromide
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BCC1043
Melanocyte stimulating hormone release inhibiting factor
Antagonizes opioid effects in vivo. Also inhibits α-MSH release
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BCC5746
UB 165 fumarate
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BCC6760
7-Hydroxy-PIPAT maleate
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BCC1927
SB-269970
SB269970 is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.
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BCC7046
(R)-3,4-DCPG
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BCC7012
(S)-3,4-DCPG
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BCC6217
PTAC oxalate
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BCC5263
Bilastine
Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria.
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BCC1565
Etoricoxib
Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
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BCC6548
DL-AP4
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BCC7923
JHW 007 hydrochloride
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BCC6846
3α-Bis-(4-fluorophenyl) methoxytropane hydrochloride
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BCC1818
Olcegepant
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.
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BCC7705
3-Bromocytisine
3-Bromocytisine (3-Br-cytisine) is a potent nACh receptors agonist, with IC50s are 0.28, 0.30 and 31.6 nM for hα4β4, hα4β2, and hα7-nACh, respectively. 3-Bromocytisine (3-Br-cytisine) shows different effects on high (HS) and low (LS) ACh sensitivity α4β2 nAChRs with EC50s are 8 and 50 nM, respectively.
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BCC6753
BTCP maleate
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BCC4583
5-hydroxymethyl Tolterodine (PNU 200577, 5-HMT, 5-HM)
Desfesoterodine (PNU-200577; Desfesoterodine) is a potent and selective muscarinic receptor antagonist with a Kb and a pA2 of 0.84 nM and 9.14, respectively.
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BCC5774
Hemokinin 1 (mouse)
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
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BCC3618
DAPT (GSI-IX)
DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.
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BCC5057
SB271046
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BCC1924
SB 271046 hydrochloride
SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
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BCC4495
Sitaxentan sodium
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors.
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BCC7702
PD 168568 dihydrochloride
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BCC6682
W-84 dibromide
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BCC5063
BMY 7378
5-HT1A partial agonist,BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3.
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BCC7469
TC 2559 difumarate
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BCC7102
5-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative
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BCC5967
Pemoline
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BCC1114
Mianserin HCl
Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
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BCC8052
SB269652
SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R); a new chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology.
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BCC1928
SB-277011
SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.
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BCC5975
α-Conotoxin AuIB
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BCC4519
Hydroxyzine 2HCl
Hydroxyzine dihydrochloride is a histamine H1-receptor antagonist.
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BCC5040
Escitalopram Oxalate
Escitalopram oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
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BCC1902
RJR-2403 oxalate
Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).
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BCC4430
Ketoprofen
Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively.
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BCC4440
Lumiracoxib
Lumiracoxib is a novel, selective COX-2 inhibitor with Ki of 0.06 μM. It also inhibits COX1 with Ki of 3 μM.
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BCC3795
Ipratropium Bromide
Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.
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BCC1329
Adoprazine
Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
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BCC6642
Bromocriptine mesylate
Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
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BCC1941
SEA0400
SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
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BCC6119
NPS 2390
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BCC7402
Lofepramine
Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.
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BCC6550
L-AP4
L-APB is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
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BCC4156
Varenicline Hydrochloride
Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist. Varenicline Hydrochloride is also a potent partial agonist of α6β2 nAChR in striatum of rats with a Ki value of 0.12 nM.
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BCC7145
PD 102807
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BCC4589
Ifenprodil Tartrate
Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.
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BCC6672
Dimaprit dihydrochloride
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BCC5915
Bay 36-7620
Non-competitive mGlu1 antagonist with inverse agonist activity
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BCC7029
U 99194 maleate
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BCC4463
Levosulpiride
Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic drug of the benzamide class.
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BCC7851
Flupenthixol dihydrochloride
Flupentixol dihydrochloride, a thioxanthene drug, is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.
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BCC5671
2-CMDO
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BCC4134
Mianserin
Mianserin is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
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BCC4580
Solifenacin succinate
Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
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BCC4427
Bufexamac
Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent.
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BCC7754
Kynurenic acid sodium salt
Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8.
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BCC6437
LED209
LED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC.
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BCC7556
(+)-Muscarine iodide
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BCC7513
Ro 64-5229
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BCC1390
Azaphen
Pipofezine(Azafen or Azaphen) is a potent inhibitor of the reuptake of serotonin.
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BCC4155
Varenicline
Varenicline (CP 526555) is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively. Varenicline is a nicotinic ligand based on the structure of cytisine, has the potential for smoking cessation treatment.
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BCC7664
PNU 177864 hydrochloride
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BCC5032
Trazodone HCl
Trazodone (hydrochloride) (AF-1161) is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
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BCC7389
J 104129 fumarate
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BCC4573
Otilonium Bromide
Octylonium bromide (SP63) is an antimuscarinic used as a spasmolytic agent.
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BCC4035
Frentizole
Frentizole, an FDA-approved immunosuppressive drug, is a novel inhibitor of the Aβ-ABAD interaction.
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BCC6490
Naproxen Sodium
Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
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BCC5056
SB269970 HCl
SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors.
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BCC4954
Fosaprepitant dimeglumine salt
Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.