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Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Products for Neuroscience

Cat.No. Product Name Information
BCC7148 LE 300
BCC7174 S 14506 hydrochloride
BCC4584 Fesoterodine Fumarate Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.
BCC7351 Ro 90-7501 Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
BCC7086 MNI-caged-L-glutamate
BCC7341 Dihydro-β-erythroidine hydrobromide Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active and competitive antagonist of neuronal nicotinic acetyicholine receptors (nAChRs). Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities.
BCC5818 Threo-methylphenidate hydrochloride
BCC6923 Pirenzepine dihydrochloride Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.
BCC6145 Ro 67-7476 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.
BCC7682 YM 202074
BCN2913 Arecoline hydrobromide Arecoline hydrobromide (Arecoline bromide) is a muscarinic acetylcholine receptor agonist.
BCC7144 SKF 77434 hydrobromide
BCC2506 Tianeptine sodium Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo.
BCC7922 Ro 01-6128
BCC7921 Ro 67-4853
BCC7700 S 24795
BCC4974 GW791343 HCl GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
BCC6632 Spaglumic acid Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.
BCC6641 Benzoquinonium dibromide Nicotinic antagonist
BCC7250 (R)-(-)-Apomorphine hydrochloride
BCC1989 TC-DAPK 6 TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP).
BCC6604 (RS)-3-Hydroxyphenylglycine
BCC6971 SIB 1757
BCC4575 Aclidinium Bromide Aclidinium Bromide(LAS 34273; LAS-W 330) is a long-acting, inhaled muscarinic antagonist as a maintenance treatment for chronic obstructive pulmonary disease (COPD).
BCC4443 Triflusal Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.
BCC6768 Imetit dihydrobromide Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).
BCC5927 Dexfenfluramine hydrochloride
BCC6154 VU 0285683
BCC7226 Nomifensine Nomifensine maleate is a selective inhibitor of dopamine uptake, used in adult attention deficit disorder.
BCC1150 Etomidate Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.
BCC7379 2-Pyridylethylamine dihydrochloride
BCC7166 HexylHIBO
BCC7167 (S)-HexylHIBO
BCN1279 (-)-Bilobalide Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba.
BCC7347 LY 456236 hydrochloride
BCC7033 UBP1112
BCC5541 Diclofensine hydrochloride Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.
BCC1487 Clozapine N-oxide (CNO) Activator of muscarinic DREAADs,Clozapine N-oxide is a pharmacologically inert metabolite of Clozapine, which is a potent 5-HT1C receptor antagonist.
BCC4531 Ketotifen Fumarate Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.
BCC7627 LY 487379 hydrochloride
BCC7896 TQS
BCN2868 Galantamine Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.
BCC1417 B-HT 920 Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.
BCC1862 Pitolisant Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
BCC1864 Pitolisant oxalate Pitolisant oxalate is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
BCC3841 Piroxicam Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.
BCC7337 4-Methylhistamine dihydrochloride Selective, high affinity H₄ agonist
BCC1743 Metoclopramide Metoclopramide is a dopamine D2 antagonist that is used as an antiemetic.
BCC4458 Lurasidone HCl Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
BCC7727 Tramiprosate Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent deposition target: Aβ In vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors.
BCC5208 Flavoxate hydrochloride Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.
BCC5529 Decloxizine Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.
BCN2170 Varenicline tartrate Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
BCC7302 ACDPP hydrochloride
BCC4147 Tarafenacin Tarafenacin(SVT-40776) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.
BCC6920 Oxotremorine M Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.
BCC5048 Desvenlafaxine Succinate Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).
BCC4133 Azatadine Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.
BCC4536 Azatadine dimaleate Azatadine dimaleate is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.
BCC6101 JNJ 5207852 dihydrochloride JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.
BCC7213 DMeOB
BCC6578 O-Phospho-L-serine O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
BCC7332 JNJ 16259685 JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
BCC4053 VU0152100 VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.
BCC4428 Etodolac Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM)
BCC4429 Flunixin Meglumin Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.
BCC3610 Semagacestat (LY450139) Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM.
BCC4434 Nabumetone Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA.
BCC4077 Lasmiditan
BCC1485 Clemizole Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.
BCN5498 2,4,5-Trimethoxybenzaldehyde Asarylaldehyde is a natural COX-2 inhibitor, which isolated from carrot (Daucus carota L.) seeds significantly inhibits cyclooxygenase II (COX-2) activity at IC50 value 100 μg/mL.
BCC5956 YM 230888
BCC6125 WY 45233 succinate
BCC4543 JNJ-7777120 JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors.
BCC5495 PEAQX PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM).
BCC1708 Lu AE58054 Hydrochloride Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.
BCC1707 Lu AE58054 Idalopirdine (Lu AE58054) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.
BCC4572 Orphenadrine Citrate Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.
BCC5972 PHA 543613 hydrochloride
BCC7528 MMPIP hydrochloride
BCC1498 CP-809101
BCC5325 9-Hydroxycalabaxanthone hydrate Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.
BCC7569 (-)-Cotinine Cotinine is an alkaloid found in tobacco and is also the predominant metabolite of nicotine, used as a biomarker for exposure to tobacco smoke.
BCC1366 AR-A014418 AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor with an IC50 of 104 nM。
BCC5923 Hemokinin 1 (human)
BCN2228 Kynurenic acid Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
BCC7535 NS 1738 NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments).
BCC4581 PNU-120596 PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.
BCC4659 Fenspiride HCl Fenspiride Hcl is an α adrenergic and H1 histamine receptor antagonist.
BCC2498 Vecuronium Bromide Vecuronium bromide (ORG NC 45) is a nondepolarizing neuromuscular blocking agent of intermediate duration.
BCC2046 Vortioxetine Vortioxetine is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
BCC4570 Homatropine Bromide Homatropine Bromide is muscarinic AChR antagonist that is an anticholinergic medication.
BCC5942 D-Amphetamine sulfate
BCC7492 Carbamoylcholine chloride Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.
BCC6679 AMI-193 Selective 5-HT₂ antagonist
BCN2867 Galanthaminone Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.
BCC4042 (S)-(+)-Ibuprofen (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects.
BCC4274 Biperiden Biperiden(KL 373) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
BCC1047 COG 133 ApoE peptide fragment; α7 nAChR antagonist
BCC4527 Cimetidine Cimetidine is a histamine-2 (H2) receptor antagonist.