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Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).

Products for Neuroscience

Cat.No. Product Name Information
BCC6113 LPYFD-NH2
BCC4425 Lornoxicam Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).
BCC5978 α-Conotoxin PnIA
BCC3808 Meloxicam (Mobic) Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.
BCC6605 (S)-3-Hydroxyphenylglycine
BCC4459 Amisulpride Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
BCC6601 (RS)-4-Carboxyphenylglycine
BCC6844 Remoxipride hydrochloride
BCC6558 S-Sulfo-L-cysteine sodium salt
BCC5050 Ketanserin Ketanserin is a selective 5-HT receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
BCC5989 ACV 1
BCC5190 Ketorolac Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
BCC4431 Ketorolac tromethamine salt Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
BCC7252 SKF 83822 hydrobromide
BCC3745 Carbenoxolone disodium
BCC4442 Zaltoprofen Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis.
BCC7165 Nemonapride
BCC6075 EHT 1864 EHT 1864 is an inhibitor of Rac family small GTPases. EHT 1864 directly binds and impairs the ability of this small GTPase to engage critical downstream effectors required for growth transformation. The Kd values are 40, 50, 60, and 230 nM for Rac1, Rac1b, Rac2 and Rac3, respectively. EHT 1864 also potently inhibits other Rac-dependent transformation processes, Tiam1- and Ras-mediated growth transformation. EHT 1864 prevents Aβ 40 and Aβ 42 production in vivo.
BCC6700 (S)-(+)-α-Methylhistamine dihydrobromide
BCC6616 4-Acetyl-1,1-dimethylpiperazinium iodide
BCC6171 ADX 10059 hydrochloride Negative allosteric modulator at mGlu₅
BCC6756 7-Hydroxy-DPAT hydrobromide
BCC6681 8-Hydroxy-DPAT hydrobromide
BCC5381 GBR 12935 GBR 12935 is a potent, and selective dopamine reuptake inhibitor.
BCC4529 Famotidine Famotidine (MK-208) is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
BCC4522 Nizatidine Nizatidine is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion.
BCC4591 MK-801 (Dizocilpine) Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive NMDA receptor antagonist, with a Kd of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux.
BCC4504 Nefiracetam Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.
BCC7028 MG 624
BCC1009 Beta-Lipotropin (1-10), porcine
BCC6929 (R)-(+)-8-Hydroxy-DPAT hydrobromide
BCC1756 MK-0974 Telcagepant (MK-0974) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.
BCC7610 CDPPB
BCC5054 Paroxetine HCl Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM.
BCC6549 D-AP4
BCC1259 Flumazenil Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
BCC7394 TC 1698 dihydrochloride
BCC6612 L-AP6
BCC4537 Azelastine HCl Azelastine hydrochloride is a potent, second-generation, selective, histamine antagonist.
BCC5059 Sertraline HCl Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
BCC1262 Loratadine Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity.
BCC4571 Homatropine Methylbromide Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.
BCC4317 EUK 134 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.
BCC4207 Cisapride
BCC6886 L-741,626 L-741626 is a selective D2 dopamine receptor antagonist, with the Ki values of 2.4, 100 and 220 nM for human D2, D3 and D4 receptors respectively.
BCC4252 Amisulpride hydrochloride Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.
BCC5276 Cabergoline Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).
BCC7524 Methimepip dihydrobromide
BCC4211 Agomelatine L(+)-Tartaric acid Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
BCC7501 Mecamylamine hydrochloride Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier.
BCC1469 Cetirizine Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
BCC4517 Cetirizine DiHCl Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
BCC1453 Cariprazine Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
BCC7184 Raclopride Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively.
BCC5901 BTS 54-505 hydrochloride
BCC5252 Sibutramine hydrochloride Sibutramine hydrochloride is a novel 5-HT (serotonin) and noradrenaline reuptake inhibitor (SNRI).
BCC6808 ICI 162,846
BCC5041 Lorcaserin HCl Lorcaserin (Hydrochloride) is a selective full agonist of human 5-HT_2C receptor with K_i of 15 nM.
BCC7920 A 582941
BCC7360 TMPH hydrochloride
BCC6600 (S)-4-Carboxy-3-hydroxyphenylglycine
BCC4598 ADX-47273 ADX-47273 is a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).
BCC7623 (±)-LY 395756
BCC6747 (+)-AJ 76 hydrochloride Antagonist; preferential action at D₂-like autoreceptors
BCC2068 Zaltidine Zaltidine(CP-57361) is a H2-receptor antagonist, which has the antisecretory action.
BCC2476 Asenapine Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.
BCC7824 CBiPES hydrochloride
BCC6917 (-)-Quinpirole hydrochloride Quinpirole Hydrochloride ((-)-LY 171555) is a high-affinity agonist of dopamine D2/D3 receptor.
BCC6200 A 844606
BCC1322 A-740003 A-740003 is a potent, selective and competitive P2X7 receptor antagonist with IC50 values are 18 and 40 nM for rat and human P2X7 receptors, respectively.
BCC6331 Methoxy-X04
BCC5695 L-745,870 trihydrochloride
BCC4209 PRX-08066 PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.
BCC1165 PRX-08066 Maleic acid PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. Phase 2.
BCC7849 BINA Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.
BCC7821 Colivelin Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury
BCC5665 (R)-(-)-α-Methylhistamine dihydrobromide (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can cross the blood-brain barrier, and can enhance memory retention, attenuates memory impairment in rats.
BCC2022 Umeclidinium bromide Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.
BCC7362 JNJ 10191584 maleate
BCC7550 A 841720 Selective mGlu₁ antagonist
BCC4290 A 839977 A 839977 is a P2X7 selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta.
BCC6182 SEN 12333
BCC6879 Isamoltane hemifumarate
BCC5696 L-741,742 hydrochloride
BCC4208 Tandospirone Tandospirone(SM-3997) is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).
BCC7985 LY 2389575 hydrochloride
BCC5564 LY2119620 LY2119620 is a high-affinity muscarinic M2/M4 receptor agonist.
BCC1011 Adrenorphin, Free Acid
BCC7936 VU 29
BCC7649 VU 1545
BCC1744 MF63 MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.
BCC5233 Aceclofenac Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.
BCC1863 Pitolisant hydrochloride Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM).
BCC5808 Spantide I
BCC7869 LY 2087101
BCC4118 Brexpiprazole Brexpiprazole (OPC-34712), an atypical antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.
BCC7788 CCMI CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction.
BCC5965 (±)-MDMA hydrochloride
BCC4194 Milnacipran Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
BCC1402 Bavisant Bavisant (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.