Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Products for Neuroscience
- AChR(52)
- Histamine Receptor(89)
- Dopamine Receptor(114)
- Histamine(3)
- AChE(3)
- SSRIs(8)
- P2X7 receptor(4)
- 5-HT Receptor(238)
- Nicotinic Receptor(61)
- Amyloid β(20)
- Muscarinic Receptor(38)
- Alzheimer(3)
- COX(44)
- GluR(115)
- Neuroscience Peptides(10)
- Substance P/NK1 Receptor(21)
- P2 Receptor(2)
- BACE(3)
- Gap Junction(8)
- CGRP(3)
- DAPK(1)
- GABA Receptor(103)
- NMDA(1)
- mPEGS-1(1)
- Cat.No. Product Name Information
-
BCC1324
A-867744
A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM.
-
BCC7384
VUF 8430 dihydrobromide
-
BCC4532
Pemirolast potassium
Pemirolast potassium (TWT-8152) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.
-
BCC4540
Desloratadine
Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies.
-
BCN5983
Rotundine
Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
-
BCC1542
Ebrotidine
Ebrotidine(FI 3542) is a competitive H2-receptor antagonist (Ki= 127.5 nM) with a potent antisecretory activity and evidenced gastroprotection.
-
BCC6991
CY 208-243
CY 208-243 is a selective dopamine D1 receptor agonist which exhibits antiparkinsonian activity.
-
BCC4579
Pyridostigmine Bromide
Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.
-
BCN1946
Hyoscyamine
L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.
-
BCC4922
Milnacipran HCl
Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
-
BCC5250
Talipexole
Talipexole (B-HT920) is a dopamine agonist that has been proposed as an antiparkinsonian agent.
-
BCC1613
GW791343 dihydrochloride
GW791343 dihydrochloride is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
-
BCC1881
rac-Rotigotine Hydrochloride
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
-
BCC7000
RJR 2429 dihydrochloride
-
BCC8074
ARN2966
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ.
-
BCC6939
AF-DX 116
Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively.
-
BCN1057
(-)-Huperzine A
(-)-Huperzine A (Huperzine A), an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
-
BCC6285
VUF 10460
VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.
-
BCC6636
MDL 73005EF hydrochloride
-
BCC5269
Acetaminophen
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
-
BCC7616
Z-Cyclopentyl-AP4
-
BCC5645
Sumatriptan
-
BCC2502
Sumatriptan Succinate
Sumatriptan succinate (GR 43175) is a serotonin1 (5-HT1) receptor agonist, which is effective in the acute treatment of migraine headache.
-
BCC4213
Ondansetron hydrochloride dihydrate
Ondansetron hydrochloride dihydrate (GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.
-
BCC4582
Trospium chloride
Trospium Chloride is a competitive muscarinic cholinergic receptor antagonist.
-
BCC6922
Zolantidine dimaleate
-
BCN2181
Pramipexole dihydrochloride
Pramipexole dihydrochloride is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
-
BCC4467
Pramipexole
Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).
-
BCC1528
Dexpramipexole dihydrochloride
Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride) is a neuroprotective agent and weak non-ergoline dopamine agonist.
-
BCC1527
Dexpramipexole
Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:
-
BCC7963
A 331440 dihydrochloride
Selective H3 antagonist
-
BCC4132
Mizolastine dihydrochloride
Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
-
BCC4027
Tropisetron Hydrochloride
Tropisetron Hydrochloride (SDZ-ICS-930) is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
-
BCC6734
Thioperamide
-
BCC3850
Risperidone
Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.
-
BCC1060
Granisetron HCl
Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
-
BCC1044
Amyloid Beta-Peptide (12-28) (human)
β-amyloid (12-28) is a peptide fragment of β-amyloid protein (β1-42). β1–42 a 42 amino acid protein , is the major component of senile plaque cores. β-amyloid (12-28) shows aggregation properties. β-amyloid (12-28) has the potential for Alzheimer’s disease research.
-
BCC1470
Cevimeline
Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia. Cevimeline can cross the blood-brain barrier (BBB).
-
BCC7116
Roxindole hydrochloride
-
BCC7121
SKF 83566 hydrobromide
-
BCC7732
A 987306
Potent and selective H4 receptor antagonist
-
BCC1454
Cariprazine hydrochloride
Cariprazine hydrochloride is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
-
BCC4521
Mizolastine
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
-
BCC6732
CGS 12066B dimaleate
-
BCC5061
WAY 100635 hydrochloride
WAY-100635 Maleate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.
-
BCC7615
VU 0155041
-
BCC5516
JNJ-31020028
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors.
-
BCC1601
Granisetron
Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
-
BCC7264
α-Bungarotoxin
-
BCC1404
Bavisant dihydrochloride hydrate
Bavisant dihydrochloride hydrate (JNJ31001074AAC) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
-
BCC6960
[Sar9,Met(O2)11]-Substance P
[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.
-
BCC6585
2,4-Dihydroxyphenylacetyl-L-asparagine
-
BCC6590
(1S,3R)-ACPD
-
BCC1877
Quetiapine
Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.
-
BCN5339
Quetiapine fumarate
Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.
-
BCC6897
Methyllycaconitine citrate
-
BCC4078
Mosapride
Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
-
BCC1065
Mosapride Citrate
Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
-
BCC4469
PD128907 HCl
PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
-
BCC3753
Chlorprothixene
Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.
-
BCC4526
Chlorpheniramine Maleate
Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM.
-
BCC7907
VU 0357017 hydrochloride
VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15).
-
BCC7766
VU 0255035
-
BCC6752
3'-Fluorobenzylspiperone maleate
-
BCC6637
MDL 72832 hydrochloride
Potent 5-HT1A ligand
-
BCC4563
Neostigmine Bromide
Neostigmine Bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis.
-
BCC6353
PAOPA
-
BCC6360
J 147
J-147 is an exceptionally potent, orally active, neuroprotective agent for cognitive enhancement. J-147 can readily pass the blood brain barrier (BBB). J-147 can inhibit monoamine oxidase B (MAO B) and the dopamine transporter with EC50 values of 1.88 μM and 0.649 μM, respectively. J-147 has potential for the treatment of Alzheimer’s disease (AD).
-
BCC1968
ST-836
ST-836 is a dopamine receptor ligand; Antiparkinsonian agent.
-
BCC6176
SR 16584
-
BCC7278
Carmoxirole hydrochloride
Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective, peripherally acting dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo.
-
BCC6693
NAN-190 hydrobromide
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.
-
BCC4148
Tarafenacin D-tartrate
Tarafenacin D-tartrate (SVT-40776 D-tartrate) is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.
-
BCC7729
VU 0238429
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.
-
BCC4596
VU 0361737
VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.
-
BCC1486
Clemizole hydrochloride
Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.
-
BCC1576
FK 3311
FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of COX-2 with antiinflammatory agent.
-
BCC4210
Agomelatine hydrochloride
Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
-
BCC7365
Desmethyl-YM 298198
-
BCC6609
L-CCG-l
-
BCC4544
Lafutidine
Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.
-
BCC7024
AF-DX 384
-
BCC1028
Myelin Basic Protein (87-99)
Major antigenic component implicated in the pathophysiology of multiple sclerosis
-
BCC5669
DPPE fumarate
-
BCC6183
Mephedrone hydrochloride
-
BCC1068
Rocuronium Bromide
Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.
-
BCC6293
CRANAD 2
-
BCC5512
mAChR-IN-1
mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM.
-
BCC6627
Arecaidine but-2-ynyl ester tosylate
-
BCC6707
5-Methylfurmethiodide
-
BCC7468
Sazetidine A dihydrochloride
-
BCC2497
Clopidogrel
Clopidogrel hydrogen sulfate is an antiplatelet agent which works by blocking platelets from sticking together and prevents them from forming harmful clots.
-
BCC6737
(±)-Vesamicol hydrochloride
-
BCC6975
(RS)-PPG
(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity.
-
BCN1058
Huperzine A
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
-
BCC6164
VU 0365114
VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM.
-
BCC1499
CP-809101 hydrochloride
CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively.
-
BCC7366
YM 298198 hydrochloride
-
BCC6790
(+)-UH 232 maleate
-
BCC7099
5-Iodo-A-85380 dihydrochloride