Neuroscience
Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides).
Products for Neuroscience
- AChR(52)
- Histamine Receptor(89)
- Dopamine Receptor(114)
- Histamine(3)
- AChE(3)
- SSRIs(8)
- P2X7 receptor(4)
- 5-HT Receptor(238)
- Nicotinic Receptor(61)
- Amyloid β(20)
- Muscarinic Receptor(38)
- Alzheimer(3)
- COX(44)
- GluR(115)
- Neuroscience Peptides(10)
- Substance P/NK1 Receptor(21)
- P2 Receptor(2)
- BACE(3)
- Gap Junction(8)
- CGRP(3)
- DAPK(1)
- GABA Receptor(103)
- NMDA(1)
- mPEGS-1(1)
- Cat.No. Product Name Information
-
BCC6796
(±)-Anatoxin A fumarate
-
BCC6695
BP 554 maleate
Selective 5-HT1A agonist
-
BCC6180
MFZ 10-7
-
BCC5289
ATB-346
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
-
BCC7887
SB 277011A dihydrochloride
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
-
BCC5113
4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
-
BCC6471
AZD3839
AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.
-
BCC7772
A 943931 dihydrochloride
Potent and selective H4 antagonist
-
BCC1342
Alosetron
Alosetron (GR 68755) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
-
BCC1343
Alosetron (Z)-2-butenedioate
Alosetron (Z)-2-butenedioate (GR 68755 (Z)-2-butenedioate) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
-
BCC1344
Alosetron Hydrochloride
Alosetron Hydrochloride (GR 68755 Hydrochloride) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
-
BCC2511
Ziprasidone HCl
Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.
-
BCC5035
Azasetron HCl
Azasetron (hydrochloride) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
-
BCC1900
Rivastigmine
Rivastigmine, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase IC50 value: 5.5 uM Target: AChE Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
-
BCC7318
PNU 282987
PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
-
BCC4565
Biperiden HCl
Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
-
BCC7314
AQ-RA 741
Selective, high affinity M2 antagonist
-
BCC1641
Iguratimod
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
-
BCC1239
VU 0364439
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.
-
BCC4054
(R)-(+)-Tolterodine
Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo.
-
BCC4586
Tolterodine tartrate
Tolterodine Tartrate (Kabi-2234; PNU-200583E) is a potent muscarinic receptor antagonist and shows selectivity for the urinary bladder over salivary glands in vivo.
-
BCC7901
TCN 238
TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM.
-
BCC5251
Sibutramine hydrochloride monohydrate
Sibutramine hydrochloride monohydrate is a novel 5-HT (serotonin) and noradrenaline reuptake inhibitor (SNRI). The IC50 for Sibutramine block of voltage-gated K+ channel (KV)4.3 is 17.3 μM.
-
BCC1908
Rotigotine hydrochloride
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
-
BCC7793
RuBi-Nicotine
-
BCC7652
NPEC-caged-(S)-3,4-DCPG
-
BCC7837
NPEC-caged-dopamine
-
BCC7818
GSK 789472 hydrochloride
-
BCC1040
Parathyroid Hormone (1-34), bovine
-
BCC7642
VU 0155041 sodium salt
-
BCC6849
SCH 23390 hydrochloride
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.
-
BCC3807
LY2886721
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment.
-
BCC7759
DL-AP4 Sodium salt
-
BCC7418
Zamifenacin fumarate
Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome.
-
BCC6159
VU 0360223
-
BCC4193
Escitalopram
Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.
-
BCC4516
Buclizine HCl
Buclizine HCl is an antihistamine and anticholinergic of the piperazine derivative family.
-
BCC3851
Rivastigmine Tartrate
Rivastigmine tartrate, an cholinesterase inhibitor(IC50= 5.5 uM), inhibits both butyrylcholinesterase and acetylcholinesterase IC50 value: 5.5 uM Target: AChE Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
-
BCC5802
GR 82334
-
BCC5034
Aripiprazole
Aripiprazole (OPC-14597) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.
-
BCC5064
Dapoxetine HCl
Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor(SSRI).
-
BCC4212
Iloperidone hydrochloride
Iloperidone (hydrochloride) is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.
-
BCC7755
CHPG Sodium salt
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..
-
BCC7756
(RS)-MCPG disodium salt
-
BCC7104
A 68930 hydrochloride
Potent, selective D1-like agonist
-
BCC5549
Decloxizine dihydrochloride
Decloxizine dihydrochloride(UCB-1402; NSC289116) is a histamine 1 receptor antagonist.
-
BCC6141
VU 0360172 hydrochloride
-
BCC6150
TC-N 22A
-
BCC1045
Amyloid Beta-Peptide (1-40) (human)
β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.
-
BCC1246
Scrambled 10Panx
Scrambled version of 10Panx, Panx-1 mimetic inhibitory peptide
-
BCC7653
NPEC-caged-(1S,3R)-ACPD
-
BCC1027
Amyloid Beta-peptide (25-35) (human)
Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.
-
BCC7263
DAU 5884 hydrochloride
-
BCC4524
Benztropine mesylate
Benzatropine mesylate is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.
-
BCC1345
Alosetron-d3 Hydrochloride
Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.
-
BCC5042
Olanzapine
Olanzapine is a selective monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic.
-
BCC7509
CP 96345
-
BCC3740
Blonanserin
Blonanserin(AD-5423) is a D2/5-HT2 receptor antagonist, atypical antipsychotic.
-
BCC1516
Darifenacin
Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
-
BCC4567
Darifenacin HBr
Darifenacin hydrobromide (UK-88525 hydrobromide) is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
-
BCC5801
GR 73632
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.
-
BCC2516
Iloperidone
Iloperidone(HP 873) is a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms.
-
BCC6927
(-)-Lobeline hydrochloride
Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
-
BCC6598
(RS)-4-Carboxy-3-hydroxyphenylglycine
-
BCC6603
(S)-4-Carboxyphenylglycine
-
BCC6224
A 412997 dihydrochloride
Selective D4 agonist
-
BCC6634
N-Acetylglycyl-D-glutamic acid
-
BCC1834
Palonosetron
Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
-
BCN2171
Palonosetron hydrochloride
Palonosetron Hcl is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
-
BCC7134
RP 67580
-
BCC7061
(S)-(+)-Dimethindene maleate
-
BCC2000
Tiotropium Bromide
Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
-
BCC3773
Duloxetine HCl
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).
-
BCC1084
Lidocaine
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative commonly used to anesthetize. Lidocaine is a drug to treat ventricular arrhythmia and an effective tumor-inhibitor.
-
BCC4438
Tolfenamic Acid
Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
-
BCN2165
Agomelatine
Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.
-
BCC6343
ML 289
-
BCC5907
FK 888
-
BCC6606
(R)-3-Carboxy-4-hydroxyphenylglycine
-
BCC2072
Ziprasidone hydrochloride monohydrate
Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
-
BCC5062
Zolmitriptan
Zolmitriptan is a novel and highly selective 5-HT(1B/1D) receptor agonist, used in the treatment of acute migraines.
-
BCC4585
Tiotropium Bromide hydrate
Tiotropium Bromide hydrate is a monohydrate of tiotropium bromide (Spiriva; Tiova; BA 679BR; tiopropium) that is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.
-
BCC7427
Milameline hydrochloride
-
BCC6845
3-CPMT
-
BCC4545
Olopatadine HCl
Olopatadine hydrochloride (ALO4943A) is a histamine blocker used to treat allergic conjunctivitis.
-
BCC6761
Aminopotentidine
-
BCC4146
Xanomeline oxalate
Xanomeline oxalate (LY246708 oxalate) is a selective M1 muscarinic receptor agonist.
-
BCC1371
Asenapine hydrochloride
Asenapine hydrochloride, an antipsychotic, is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and Dopamine (D2, D3, D4) receptor antagonist with Ki values of 0.03-4.0 nM for 5-HT and 1.3, 0.42, 1.1 nM for Dopamine receptor, respectively.
-
BCC1969
ST-836 hydrochloride
-
BCC5935
Catestatin
-
BCC6744
Amthamine dihydrobromide
-
BCC5053
Naratriptan
Naratriptan hydrochloride is a selective 5-HT1 receptor subtype agonist and is a triptan drug that is used for the treatment of migraine headaches.
-
BCC1906
Rocuronium
Rocuronium (Org-9426) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia.
-
BCC6615
1-Acetyl-4-methylpiperazine hydrochloride
-
BCC6345
ML 337
-
BCC3834
Paliperidone
Paliperidone (9-hydroxyrisperidone) is a dopamine antagonist of the atypical antipsychotic class of medications.
-
BCC4154
ML314
ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.
-
BCN6255
Pregnenolone
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication.
-
BCC6898
Piribedil dihydrochloride
-
BCC6800
8-Hydroxy-PIPAT oxalate