GPCR/G protein
G protein–coupled receptors (GPCRs) which are also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors, that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.
Products for GPCR/G protein
- GIP Receptor(2)
- FFAR1 (GPR40)(7)
- 5-HT Receptor(238)
- Urotensin-II Receptor(10)
- CCK2 Receptors(7)
- P2Y Receptor(25)
- EP4 Receptor(3)
- CRF1 Receptors(6)
- Melatonin Receptors(9)
- LPL Receptor(1)
- Adenosine Receptor(54)
- VIP Receptors(7)
- OX Receptor(15)
- Chemokine Receptors(16)
- Neurotensin Receptors(7)
- Prostanoid Receptors(21)
- CCK1 Receptors(5)
- Adrenergic Receptor(136)
- GPR119(5)
- Calcium-Sensing Receptor(3)
- Cannabinoid Receptor(36)
- Angiotensin Receptor(21)
- GPR120(2)
- Protease-Activated Receptors(9)
- PAF Receptors(3)
- Sigma Receptor(24)
- NK3 Receptor(6)
- NPY Receptors(23)
- Glucagon Receptor(16)
- Leukotriene Receptor(9)
- Bombesin Receptors(14)
- Sphingosine(14)
- CXCR(16)
- NOP Receptor(21)
- GPR55(5)
- Galanin Receptors(11)
- Endothelin Receptor(11)
- GPR35(7)
- Glucocorticoid Receptor(17)
- Calcitonin and Related Receptors(10)
- Bradykinin Receptors(12)
- mGluR(11)
- Adenosine Kinase(2)
- GPR109A(2)
- GPCR19(1)
- Non-selective CRF(7)
- LTD4 Receptor(1)
- Secretin Receptors(1)
- Melanocortin (MC) Receptors(16)
- ETB Receptors(5)
- NK2 Receptors(7)
- LPA Receptor(5)
- S1P receptor inhibitor(5)
- CCR2(5)
- Hydroxycarboxylic Acid Receptors(5)
- PACAP Receptors(3)
- Melanin-concentrating Hormone Receptors(7)
- Vasopressin Receptor(10)
- Somatostatin Receptor(15)
- TSH Receptor(1)
- Peptide Receptors(8)
- Ghrelin Receptors(9)
- ETA Receptors(3)
- Orphan 7-TM Receptors(6)
- Oxytocin Receptors(4)
- Ras(6)
- Heterotrimeric(1)
- CysLT1 receptor(1)
- Motilin Receptor(4)
- Acetylcholine(3)
- Prostaglandin Receptor(4)
- GHSR(4)
- EBI2/GPR183(1)
- Gonadotropin-Releasing Hormone Receptors(3)
- Orexin(3)
- Apelin Receptor(5)
- CRF2 Receptors(3)
- Calcimimetic Agent(2)
- Adrenergic Transporters(5)
- CaSR(3)
- EP1 Receptor(1)
- Sensory Neuron-Specific Receptors(1)
- 17,20-lyase(3)
- Adenosine Deaminase(3)
- NK Receptor(1)
- PGD2 Receptor(1)
- GLUT1(1)
- RGS(2)
- GPR44(1)
- Adiponectin Receptor(1)
- ERRγ(1)
- Cat.No. Product Name Information
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BCC6861
Xamoterol hemifumarate
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BCC6256
SB 706375
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BCC4218
Doxazosin
Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
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BCC5715
Somatostatin 1-28
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BCC7522
PAF (C16)
Endogenous platelet-activating factor (PAF)
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BCC5792
Sauvagine
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BCC4963
Alprostadil
Alprostadil is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
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BCC5809
GRP (porcine)
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BCC6652
5-Carboxamidotryptamine maleate
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BCC6708
PRE-084 hydrochloride
PRE-084 hydrochloride is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.
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BCC4203
TAK-700 R-form
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BCC4358
Indacaterol Maleate
Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
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BCC7090
Rimcazole dihydrochloride
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BCC5963
[Nle4,D-Phe7]-α-MSH
Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH), for gaining a tan.
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BCC5711
Pancreatic Polypeptide (human)
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
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BCC4079
Detomidine
Detomidine produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist Target: α2-adrenergic agonist Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses.
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BCC6967
SR 57227 hydrochloride
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BCC1257
Doxazosin Mesylate
Doxazosin mesylate (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.
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BCC5985
[Orn5]-URP
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BCC7247
Iloprost
Iloprost (ZK 36374) is a synthetic analogue of prostacyclin PGI2.
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BCC5200
SB-334867 free base
SB-334867 free base (SB334867A free base) is an excellent, selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.
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BCC6798
Idazoxan hydrochloride
Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism.
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BCC5499
RG7090
Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
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BCC4907
Fluticasone propionate
Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.
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BCN4344
Grifolic acid
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BCC6875
Imiloxan hydrochloride
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BCC7191
Seglitide
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BCC2494
Alfuzosin HCl
Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
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BCC4080
Alfuzosin
Alfuzosin is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
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BCC5832
Neuromedin C (porcine)
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BCC5431
Bambuterol
Bambuterol ((±)-Bambuterol; KWD-2183) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.
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BCC7399
LP 44
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BCC7479
Nefazodone hydrochloride
Nefazodone hydrochloride is an antidepressant drug.
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BCC4223
Perindopril
Perindopril is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease.
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BCC2256
Methylprednisolone
Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties.
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BCC5643
Octreotide acetate
Octreotide is a somatostatin analog that binds to the somatostatin receptor, mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production.
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BCC5389
APD668
APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively.
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BCC6341
4-[4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1,4-dihydropyrrolo[3,4-d]pyrazol-5-yl]benzoic acid
CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM.
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BCC5712
CGRP (rat)
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BCC7693
Cyclosomatostatin
Non-selective sst receptor antagonist
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BCC4486
Mifepristone
Mifepristone is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
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BCC7018
CP 94253 hydrochloride
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BCC5663
2-Methyl-5-hydroxytryptamine hydrochloride
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects.
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BCC6210
SHA 68
SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
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BCC6208
S 32212 hydrochloride
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BCC5775
UFP-101
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BCC7854
PF9 tetrasodium salt
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BCC4507
OC000459
OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM. Phase 2.
Cas: 851723-84-7
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BCC7746
PF 514273
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BCC4111
NBI-74330
NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
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BCC1946
Setiptiline maleate
Setiptiline is a serotonin receptor antagonist.
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BCC5408
PSN632408
PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 uM, respectively.
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BCC6664
1,3-Dipropyl-8-phenylxanthine
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BCC7142
GR 125487 sulfamate
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BCC5929
M617
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BCC7795
SKF 86466 hydrochloride
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BCC1364
Anamorelin hydrochloride
Anamorelin hydrochloride is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
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BCC5021
Azilsartan Medoxomil
Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
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BCC4089
Azilsartan medoxomil monopotassium
Azilsartan medoxomil monopotassium is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension.
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BCC1736
Medetomidine
Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively).
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BCC4351
Medetomidine HCl
Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.
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BCC6047
C 021 dihydrochloride
Potent CCR4 antagonist
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BCC7594
SB 699551
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BCC6149
TC-MCH 7c
TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrable MCH1R antagonist with an IC50 of 5.6 nM for hMCH1R. TC-MCH 7c has Kis of 3.4 nM and 3.0 nM of human and mouse MCH1R, respectively.
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BCC6387
AMG837
AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
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BCC5973
[Ala2,8,9,11,19,22,24,25,27,28]-VIP
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BCC5710
CRF (human, rat)
Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
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BCC4411
Org 27569
Org 27569 is a potent CB1 receptor allosteric modulator, which increases agonist binding, yet blocks agonist-induced CB1 signaling.
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BCC5912
Obestatin (rat)
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BCC2011
Tozadenant
Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
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BCC7214
Ritanserin
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
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BCC1752
MK 0893
MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM.
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BCC5841
Neuromedin B (porcine)
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.
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BCC8036
TCS 3035
GPR35 agonist
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BCC5122
Almorexant
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively.
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BCC4599
CTEP (RO4956371)
CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.
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BCC7802
WAY 207024 dihydrochloride
GnRH receptor antagonist
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BCC1531
Dipraglurant
Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.
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BCC7413
ZK 756326
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BCC7826
YIL 781
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BCC6278
ML 221
ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
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BCC5827
Glucagon-like peptide 1 (1-37) (human, rat)
Glucagon-like peptide 1 (1-37), human is a highly potent agonist of the GLP-1 receptor.
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BCC4189
S1RA
S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
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BCC6899
CP 93129 dihydrochloride
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BCC5917
UFP 803
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BCC1358
AMD-070 hydrochloride
AMD-070 (hydrochloride) is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
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BCC6163
26RFa
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BCC4083
L-(-)-α-Methyldopa hydrochloride
L-(-)-α-Methyldopa hydrochloride is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.
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BCC1102
GW9508
GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities.
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BCC1646
INCB 3284 dimesylate
INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 dimesylate can be used in the research of acute liver failure.
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BCC5960
Galanin (porcine)
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BCC1710
LUF6000
LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).
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BCC6797
Efaroxan hydrochloride
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BCC4346
Detomidine HCl
Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist Target: α2-adrenergic agonist Detomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses.
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BCC4110
SCH 546738
SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
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BCC5314
Atosiban
Atosiban(RW22164; Tractocile) is a nonapeptide, desamino-oxytocin analogue, and a competitive vasopressin/oxytocin receptor antagonist (VOTra).
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BCC5727
α-helical CRF 9-41
CRF receptor antagonist
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BCC5930
M871
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BCC5962
α-CGRP (human)
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BCC7723
W146
W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.