Membrane Transporter/Ion Channel
Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins)
Products for Membrane Transporter/Ion Channel
- P2X purinergic receptor(31)
- Calcium Channel(77)
- Potassium Channel(80)
- NMDA Receptor(80)
- Sodium Channel(43)
- ATPase(32)
- TRP Channel(44)
- Proton Pump(12)
- AMPAR(49)
- GABA Receptor(103)
- Glycine Transporters(6)
- Chloride Channels(11)
- Glutamate (EAAT) Transporters(19)
- GTPase(7)
- Other Channel Modulators(7)
- CFTR(10)
- Multidrug Transporters(4)
- M2 ion Channel(1)
- Monoamine transporter(4)
- P-gp(6)
- TRPV1(4)
- MCT(2)
- Na+/Ca2+ Exchanger(7)
- Cannabinoid Transporters(7)
- Nucleoside Transporters(3)
- Lipophilic platinum complex(1)
- Monocarboxylate Transporters(1)
- NKCC(2)
- Gardos Channel(1)
- Glycine Receptors(1)
- MCT2(2)
- Glucose Transporters(1)
- ICB(2)
- GlyT1(2)
- Kv1.3(1)
- URAT1(1)
- Cat.No. Product Name Information
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BCC7488
ω-Agatoxin IVA
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BCC6739
FGIN-1-43
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BCC7710
Kaliotoxin
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BCC5873
CALP1
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BCC5000
Mitiglinide Calcium
Mitiglinide Calcium (KAD-1229; S21403) is a drug for the treatment of type 2 diabetes; it is a highly selective KATP channel antagonist.
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BCC7176
NNC 711
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BCC7709
Margatoxin
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.
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BCC6673
Dantrolene, sodium salt
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BCC5554
7ACC2
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.
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BCC6831
ZM 226600
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BCC5699
ω-Conotoxin MVIIC
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BCN2175
Pregabalin
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BCC6934
CGP 54626 hydrochloride
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BCC5737
CGP 55845 hydrochloride
Potent, selective GABAB antagonist
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BCC6631
Arcaine sulfate
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BCC5536
Azimilide Dihydrochloride
Azimilide Dihydrochloride (NE-10064 Dihydrochloride) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
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BCC5535
Azimilide
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BCC6427
Retigabine
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BCC1890
Retigabine dihydrochloride
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BCC6755
L-701,252
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BCC4747
Verapamil HCl
Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel antagonist.
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BCC7471
U 93631
U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors.
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BCC7340
Gavestinel
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BCC7779
NS 1619
NS-1619 is a selective large conductance Ca2+-activated K+-channel activator.
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BCC4177
Dofequidar fumarate
Dofequidar fumarate(MS-209 fumarate), an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both.
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BCC7455
YM 90K hydrochloride
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BCC1359
Ampalex
Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
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BCC1993
Tezampanel
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BCC5742
Ryanodine
Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.
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BCC7470
Org 20599
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BCC6431
Rostafuroxin (PST 2238)
Rostafuroxin(PST 2238) is a antihypertensive compound; Na,K-ATPase antognist;displaced [3H]ouabain from the dogkidney Na+,K+-ATPase with IC50 of 1.5 nM.
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BCC7466
U 89843A
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BCC1804
Noopept
Omberacetam (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.
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BCC7117
(S)-SNAP 5114
(S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug.
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BCC7489
ω-Agatoxin TK
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BCC6432
CARIPORIDE
Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.
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BCC6873
MPDC
MPDC is a potent and competitive inhibitor of the Na+-dependent high-affinity glutamate transporter in forebrain synaptosomes.
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BCC8041
Huwentoxin XVI
Potent and reversible N-type Ca2+ channel blocker
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BCC7095
SB 205384
GABAA receptor modulator; slows current decay
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BCC7331
DMP 543
DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer.
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BCC7339
ZK 200775
Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
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BCC4376
Esomeprazole Sodium
Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
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BCC7674
Benzamil
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
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BCC6378
Talampanel(LY300164)
Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED).
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BCC5007
Esomeprazole Magnesium
Esomeprazole magnesium is an inhibitor of H+, K+-ATPase, effectively used in the research of upper intestinal disorder.
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BCC6107
Flunitrazepam
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BCC7055
Chromanol 293B
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BCC7080
(-)-[3R,4S]-Chromanol 293B
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BCC7153
Autocamtide-2-related inhibitory peptide
Selective CaM kinase II inhibitor
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BCC4401
Clevidipine Butyrate
Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.
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BCC2074
Zosuquidar
Zosuquidar (LY335979) is a potent negative modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
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BCC3878
LY335979 (Zosuquidar 3HCL)
Zosuquidar trihydrochloride is an inhibitor of P-glycoprotein with a Ki value of 59 nM.
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BCC8026
Agitoxin 2
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BCC4158
Ro 25-6981
Ro 25-6981 is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively.
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BCC4279
Reserpine hydrochloride
Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).
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BCC6926
(RS)-AMPA hydrobromide
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BCC4278
NBI-98854
Trans (2,3)-Dihydrotetrabenazine ((2R,3R,11bR)-rel-Dihydrotetrabenazine), a metabolite of Tetrabenazine, shows remarkable inhibition activity on vesicular monoamine transporter (VMAT2).
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BCC6866
SYM 2206
SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist.
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BCC3849
Riluzole
Riluzole is an anticonvulsant drug and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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BCC5068
Amiloride HCl dihydrate
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel.
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BCC1939
SDZ 220-581
SDZ 220-581 is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
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BCC6992
SDZ 220-040
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BCC6081
S 18986
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.
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BCC7077
PPAHV
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BCC6931
CFM-2
CFM-2 is a selective non-competitive AMPAR antagonist.
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BCC4157
SDZ 220-581 hydrochloride
SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
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BCC1940
SDZ 220-581 Ammonium salt
SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
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BCC6577
7-Chlorokynurenic acid
7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.
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BCC4406
Bupivacaine HCl
Bupivacaine Hydrochloride is a local anaesthetic drug belonging to the amino amide group.
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BCC7439
Co 102862
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BCC6981
Cyclopiazonic acid
Cyclopiazonic acid (CPA), a neurotoxic secondary metabolite (SM) made by A. flavus, is a nanomolar inhibitor of endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA) and a potent inducer of cell death in plants.
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BCC7618
KC 12291 hydrochloride
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BCC7777
BL 1249
BL-1249 is a nonsteroidal anti-inflammatory drug (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM).
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BCC1676
KB-R7943 mesylate
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.
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BCC6730
Synthalin sulfate
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BCC6903
TPMPA
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BCC7472
NNC 05-2090 hydrochloride
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BCC6087
TCS 1105
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BCC5982
Ketamine hydrochloride
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BCC1809
NS309
NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels.
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BCC7984
MaxiPost
Flindokalner (BMS-204352) is a potassium channel modulator. Flindokalner is a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is also a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner shows a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM), and acts as a negative modulator of GABAA receptors. Flindokalner shows anxiolytic efficacy in vivo.
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BCC4045
AWD 131-138
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BCC2253
Tipifarnib (Zarnestra)
Tipifarnib (R115777; IND 58359) is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib (R115777; IND 58359) binds to and inhibits farnesyltransferase (FTase) with IC50 of 0.6 nM.
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BCC6725
PPADS tetrasodium salt
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca²⁺exchanger in guinea pig airway smooth muscle.
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BCC7369
Co 101244 hydrochloride
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BCC6326
GaTx2
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BCC8038
TRAM 39
Potent KCa3.1 blocker
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BCC4377
Amiodarone HCl
Amiodarone hydrochloride is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 19.1 μM.
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BCC6945
AM 404
Vanilloid receptor agonist. Also anandamide transport inhibitor
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BCC7520
CP 465022 hydrochloride
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BCC7016
UCL 1684
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BCC7168
ALX 5407 hydrochloride
Selective non-transportable GlyT1 inhibitor
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BCC7671
Valinomycin
Valinomycin (NSC 122023) is a cyclic depsipeptide antibiotic first isolated from Streptomyces fulvissimus, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells. Valinomycin induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
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BCC6660
Dilazep dihydrochloride
Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides.
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BCC7448
BMS 191011
BMS-191011 (BMS-A) is an opener of the large-conductance, Ca2++-activated potassium (maxi-K) channel, effective in stroke models.
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BCC7844
Ralfinamide mesylate
Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain.
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BCC5980
Conantokin-R
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BCC6964
NF 279
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BCC5952
SNX 482
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BCC4387
Brefeldin A
Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus. Brefeldin A is also an autophagy and mitophagy inhibitor. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.