Membrane Transporter/Ion Channel
Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins)
Products for Membrane Transporter/Ion Channel
- P2X purinergic receptor(31)
- Calcium Channel(77)
- Potassium Channel(80)
- NMDA Receptor(80)
- Sodium Channel(43)
- ATPase(32)
- TRP Channel(44)
- Proton Pump(12)
- AMPAR(49)
- GABA Receptor(103)
- Glycine Transporters(6)
- Chloride Channels(11)
- Glutamate (EAAT) Transporters(19)
- GTPase(7)
- Other Channel Modulators(7)
- CFTR(10)
- Multidrug Transporters(4)
- M2 ion Channel(1)
- Monoamine transporter(4)
- P-gp(6)
- TRPV1(4)
- MCT(2)
- Na+/Ca2+ Exchanger(7)
- Cannabinoid Transporters(7)
- Nucleoside Transporters(3)
- Lipophilic platinum complex(1)
- Monocarboxylate Transporters(1)
- NKCC(2)
- Gardos Channel(1)
- Glycine Receptors(1)
- MCT2(2)
- Glucose Transporters(1)
- ICB(2)
- GlyT1(2)
- Kv1.3(1)
- URAT1(1)
- Cat.No. Product Name Information
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BCC7229
ZK 93426 hydrochloride
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BCC7566
GYKI 47261 dihydrochloride
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BCC4593
(-)-MK 801
(-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects.
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BCC6322
PF 4778574
PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.
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BCC5006
ML133 HCl
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.
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BCC6787
GBLD 345
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BCC5076
Ibutilide Fumarate
Ibutilide fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm.
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BCC7478
Philanthotoxin 74
Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.
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BCC5888
MNI-caged-NMDA
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BCC7232
XE 991 dihydrochloride
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively.
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BCC4400
Azelnidipine
Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.
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BCC7644
rac BHFF
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BCC6193
PHP 501 trifluoroacetate
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BCC6988
CGP 35348
Brain penetrant, selective GABAB antagonist
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BCC6990
CGP 46381
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BCC7605
CGP 36216 hydrochloride
GABAB antagonist; displays activity at presynaptic receptors
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BCC6292
QNZ 46
QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively).
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BCC6588
(R)-(+)-HA-966
(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.
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BCC5705
Picrotoxin
Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR. Picrotoxin (Cocculin) causes overstimulation and induces convulsions.
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BCC7874
KS 176
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
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BCC6419
RQ-00203078
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
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BCC6580
Saclofen
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BCC5771
LY 233053
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BCC7789
NPEC-caged-(S)-AMPA
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BCC1182
TAK-438
Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.
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BCC6401
GS967
GS967 (GS-458967) is a potent, and selective inhibitor of cardiac late sodium current (late INa ) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
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BCC7957
Penitrem A
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals.
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BCC7757
7-Chlorokynurenic acid sodium salt
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.
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BCC6581
(R)-CPP
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BCC7898
A 887826
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo.
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BCC3602
KN-62
KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.
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BCC7254
Y-27152
Y-27152, a prodrug of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
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BCC7253
Y-26763
Y-26763 is a K+ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K+ (KATP) channel activator.
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BCC5977
Conantokin-T
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BCC6626
SKF 97541
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BCC7078
CGP 37849
CGP 37849 is a potent, competitive and orally active N-methyl-D-aspartate (NMDA) receptor antagonist. CGP 37849 is an anticonvulsant in rodents and has antidepressant and anxiolytic-like effects.
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BCC7053
CGP 39551
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BCC7736
Pregnanolone
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BCC7186
N-ArachidonylGABA
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BCC7079
Suramin hexasodium salt
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin sodium salt is an antitrypanosomal, anti-neoplastic and anti-angiogenic agent.
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BCC6932
Iberiotoxin
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BCC4176
Dofequidar
Dofequidar(MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.
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BCC6594
N-(4-Hydroxyphenylacetyl)spermine
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BCC7753
DL-AP5 Sodium salt
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BCC7023
L-655,708
L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM).
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BCC6953
SKF 96365 hydrochloride
SKF-96365 hydrochloride is a non-selective TRP Channel blocker.
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BCC4059
MDL-29951
MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
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BCC7847
Sipatrigine
Sipatrigine, a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has potential to treat focal cerebral ischemia and stroke.
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BCC6592
5,7-Dichlorokynurenic acid
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BCC4159
Ro 25-6981 Maleate
Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
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BCC7655
Ro 8-4304 hydrochloride
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BCC7508
threo Ifenprodil hemitartrate
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BCC5786
pep2-EVKI
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BCC5787
pep2-AVKI
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BCC5785
pep2-SVKE
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BCC6126
VU 591 hydrochloride
VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM.
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BCC1083
Cilnidipine
Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
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BCC6984
CCMQ
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BCC5238
Lercanidipine hydrochloride
Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.
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BCC6884
ZD 7288
ZD7288 is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
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BCC6825
AM 92016 hydrochloride
AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse.
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BCC4199
TRPC6 inhibitor
SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
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BCC8009
GSK 2193874
GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50s of 2 nM and 40 nM for rTRPV4 and hTRPV4.
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BCC1915
Safinamide
Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.
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BCC6602
(R)-4-Carboxyphenylglycine
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BCC7276
Ro 0437626
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BCC7465
U 90042
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BCC6207
ML 218 hydrochloride
ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.
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BCC5008
Zinc Pyrithione
Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.
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BCC5604
ML 240
ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
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BCC2504
Repaglinide
Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.
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BCC7825
trans-Ned 19
trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations.
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BCC3858
Strontium Ranelate
Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate also can activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling.
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BCC4191
Nav1.7 inhibitor
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BCC4399
Tetracaine HCl
Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
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BCC7287
PALDA
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BCC7784
UK 78282 hydrochloride
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BCC3856
Sodium Orthovanadate
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
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BCC6892
LY 235959
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BCC6599
(RS)-(Tetrazol-5-yl)glycine
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice.
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BCC1451
Capsazepine
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.
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BCC6774
L-689,560
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.
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BCC1683
KN-93
CaM kinase II inhibitor; also K+ channel blocker (KV),KN-93 is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with Ki of 370 nM.
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BCC6333
Purotoxin 1
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BCC6989
CGP 52432
CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
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BCC7976
ML 277
ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.
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BCC6596
(S)-(-)-5-Fluorowillardiine
(S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.
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BCC6805
(2R,3S)-Chlorpheg
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BCC5951
PEPA
PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
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BCC6966
MRS 2219
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BCC4777
Dronedarone HCl
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.
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BCN2176
Dronedarone
Dronedarone (SR 33589) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.
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BCC7519
WS 3
β cell proliferation agonist WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).
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BCC6842
L-701,324
L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
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BCC7882
CP 100356 hydrochloride
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BCC6738
FGIN-1-27
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BCC1681
KN-92 hydrochloride
KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
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BCC7327
LOE 908 hydrochloride
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BCC7407
GYKI 53655 hydrochloride
GYKI53655 hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.
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BCN6250
Hispidulin
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.