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Membrane Transporter/Ion Channel

Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins)

Products for Membrane Transporter/Ion Channel

Cat.No. Product Name Information
BCC7229 ZK 93426 hydrochloride
BCC7566 GYKI 47261 dihydrochloride
BCC4593 (-)-MK 801 (-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects.
BCC6322 PF 4778574 PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.
BCC5006 ML133 HCl ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.
BCC6787 GBLD 345
BCC5076 Ibutilide Fumarate Ibutilide fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm.
BCC7478 Philanthotoxin 74 Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.
BCC5888 MNI-caged-NMDA
BCC7232 XE 991 dihydrochloride XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively.
BCC4400 Azelnidipine Azelnidipine(CS 905; Calblock) is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive.
BCC7644 rac BHFF
BCC6193 PHP 501 trifluoroacetate
BCC6988 CGP 35348 Brain penetrant, selective GABA_B antagonist
BCC6990 CGP 46381
BCC7605 CGP 36216 hydrochloride GABA_B antagonist; displays activity at presynaptic receptors
BCC6292 QNZ 46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively).
BCC6588 (R)-(+)-HA-966 (R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.
BCC5705 Picrotoxin Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR. Picrotoxin (Cocculin) causes overstimulation and induces convulsions.
BCC7874 KS 176 KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
BCC6419 RQ-00203078 RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
BCC6580 Saclofen
BCC5771 LY 233053
BCC7789 NPEC-caged-(S)-AMPA
BCC1182 TAK-438 Vonoprazan Fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3.
BCC6401 GS967 GS967 (GS-458967) is a potent, and selective inhibitor of cardiac late sodium current (late INa ) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
BCC7957 Penitrem A Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals.
BCC7757 7-Chlorokynurenic acid sodium salt 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.
BCC6581 (R)-CPP
BCC7898 A 887826 A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo.
BCC3602 KN-62 KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.
BCC7254 Y-27152 Y-27152, a prodrug of the KATP (Kir6) channel opener Y-26763, is a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
BCC7253 Y-26763 Y-26763 is a K+ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K+ (KATP) channel activator.
BCC5977 Conantokin-T
BCC6626 SKF 97541
BCC7078 CGP 37849 CGP 37849 is a potent, competitive and orally active N-methyl-D-aspartate (NMDA) receptor antagonist. CGP 37849 is an anticonvulsant in rodents and has antidepressant and anxiolytic-like effects.
BCC7053 CGP 39551
BCC7736 Pregnanolone
BCC7186 N-ArachidonylGABA
BCC7079 Suramin hexasodium salt Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM). Suramin sodium salt is an antitrypanosomal, anti-neoplastic and anti-angiogenic agent.
BCC6932 Iberiotoxin
BCC4176 Dofequidar Dofequidar(MS-209) is a novel quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR.
BCC6594 N-(4-Hydroxyphenylacetyl)spermine
BCC7753 DL-AP5 Sodium salt
BCC7023 L-655,708 L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM).
BCC6953 SKF 96365 hydrochloride SKF-96365 hydrochloride is a non-selective TRP Channel blocker.
BCC4059 MDL-29951 MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
BCC7847 Sipatrigine Sipatrigine, a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has potential to treat focal cerebral ischemia and stroke.
BCC6592 5,7-Dichlorokynurenic acid
BCC4159 Ro 25-6981 Maleate Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit.
BCC7655 Ro 8-4304 hydrochloride
BCC7508 threo Ifenprodil hemitartrate
BCC5786 pep2-EVKI
BCC5787 pep2-AVKI
BCC5785 pep2-SVKE
BCC6126 VU 591 hydrochloride VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM.
BCC1083 Cilnidipine Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
BCC6984 CCMQ
BCC5238 Lercanidipine hydrochloride Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.
BCC6884 ZD 7288 ZD7288 is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
BCC6825 AM 92016 hydrochloride AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse.
BCC4199 TRPC6 inhibitor SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.
BCC8009 GSK 2193874 GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC50s of 2 nM and 40 nM for rTRPV4 and hTRPV4.
BCC1915 Safinamide Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.
BCC6602 (R)-4-Carboxyphenylglycine
BCC7276 Ro 0437626
BCC7465 U 90042
BCC6207 ML 218 hydrochloride ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier.
BCC5008 Zinc Pyrithione Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.
BCC5604 ML 240 ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
BCC2504 Repaglinide Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus.
BCC7825 trans-Ned 19 trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations.
BCC3858 Strontium Ranelate Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate also can activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling.
BCC4191 Nav1.7 inhibitor
BCC4399 Tetracaine HCl Tetracaine HCl is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
BCC7287 PALDA
BCC7784 UK 78282 hydrochloride
BCC3856 Sodium Orthovanadate Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
BCC6892 LY 235959
BCC6599 (RS)-(Tetrazol-5-yl)glycine (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice.
BCC1451 Capsazepine Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM.
BCC6774 L-689,560 L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.
BCC1683 KN-93 CaM kinase II inhibitor; also K⁺ channel blocker (K_V),KN-93 is a novel membrane-permeant synthetic inhibitor of purified neuronal CaMK-II, with K_i of 370 nM.
BCC6333 Purotoxin 1
BCC6989 CGP 52432 CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM.
BCC7976 ML 277 ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM.
BCC6596 (S)-(-)-5-Fluorowillardiine (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist.
BCC6805 (2R,3S)-Chlorpheg
BCC5951 PEPA PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
BCC6966 MRS 2219
BCC4777 Dronedarone HCl Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.
BCN2176 Dronedarone Dronedarone (SR 33589) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.
BCC7519 WS 3 β cell proliferation agonist WS3 is a novel small molecule that promotes β cell proliferation with EC50 of 28 nM(induced R7T1 proliferation).
BCC6842 L-701,324 L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
BCC7882 CP 100356 hydrochloride
BCC6738 FGIN-1-27
BCC1681 KN-92 hydrochloride KN-92 is an inactive derivative of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
BCC7327 LOE 908 hydrochloride
BCC7407 GYKI 53655 hydrochloride GYKI53655 hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.
BCN6250 Hispidulin Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC50 of 2.71 μM.