Membrane Transporter/Ion Channel
Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins)
Products for Membrane Transporter/Ion Channel
- P2X purinergic receptor(31)
- Calcium Channel(77)
- Potassium Channel(80)
- NMDA Receptor(80)
- Sodium Channel(43)
- ATPase(32)
- TRP Channel(44)
- Proton Pump(12)
- AMPAR(49)
- GABA Receptor(103)
- Glycine Transporters(6)
- Chloride Channels(11)
- Glutamate (EAAT) Transporters(19)
- GTPase(7)
- Other Channel Modulators(7)
- CFTR(10)
- Multidrug Transporters(4)
- M2 ion Channel(1)
- Monoamine transporter(4)
- P-gp(6)
- TRPV1(4)
- MCT(2)
- Na+/Ca2+ Exchanger(7)
- Cannabinoid Transporters(7)
- Nucleoside Transporters(3)
- Lipophilic platinum complex(1)
- Monocarboxylate Transporters(1)
- NKCC(2)
- Gardos Channel(1)
- Glycine Receptors(1)
- MCT2(2)
- Glucose Transporters(1)
- ICB(2)
- GlyT1(2)
- Kv1.3(1)
- URAT1(1)
- Cat.No. Product Name Information
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BCC1660
Istaroxime
Istaroxime (PST2744) is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM.
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BCC7993
BCH
LAT1-IN-1 (BCH) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis.
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BCC5735
DL-TBOA
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively.
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BCC5779
L-R4W2
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BCC3625
Tariquidar
Tariquidar is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM).
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BCC7510
TB 21007
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BCC6619
(±)-1-(1,2-Diphenylethyl)piperidine maleate
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BCC6749
iso-PPADS tetrasodium salt
P2X antagonist
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BCN5359
Digoxin
Digoxin is a potent inhibitor of Na+/K+-ATPase, has the potential for arrhythmia and heart failure treatment.
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BCC5002
Gliclazide
Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Gliclazide is used as an antidiabetic.
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BCC7532
CX 546
CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.
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BCC1559
Esomeprazole Magnesium trihydrate
Esomeprazole Magnesium trihydrate is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
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BCC1560
Etifoxine
Etifoxine(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors.
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BCC7706
PD 173212
PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.
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BCC5106
BTB06584
BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.
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BCC5990
ShK-Dap22
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BCC6584
ACBC
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BCC7817
YM 58483
YM-58483 is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals.
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BCC6974
IDRA 21
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BCC6759
Cyclothiazide
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BCC4298
Lansoprazole sodium
Lansoprazole sodium(AG-1749) is a proton pump inhibitor which prevents the stomach from producing acid.
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BCC7646
AZ 11645373
Potent and selective human P2X7 antagonist
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BCC7294
(±)-HIP-A
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BCC7295
(±)-HIP-B
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BCC6688
Ifenprodil hemitartrate
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BCC6170
MK 0343
MK0343 (MRK-409) is an orally bioavailable GABAA receptor subtype-selective partial agonist. MK0343 is a non-sedating anxiolytic.
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BCC5067
Ambroxol HCl
Na+ channel blocker,AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
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BCC7545
Alphaxalone
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BCC6889
QX 314 bromide
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.
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BCC7461
Zoniporide dihydrochloride
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BCC7141
Apamin
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.
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BCC5782
pep2m
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BCC5783
pep4c
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BCN2325
Nonivamide
Nonivamide is a agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.
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BCC6685
trans-4-Hydroxycrotonic acid
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BCC6032
N2-Methyl-L-arginine
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BCC1751
Miriplatin hydrate
Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents.
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BCC7675
AM 1172
FAAH inhibitor; also anandamide uptake inhibitor and CB receptor partial agonist
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BCC5740
Tertiapin-Q
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BCC4904
Felbamate
Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
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BCC6591
Ibotenic acid
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
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BCC7885
IEM 1925 dihydrobromide
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BCC5898
CALP2
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BCC5900
CALP3
CALP3, a Ca2+-like peptide, is a potent Ca2+ channel blocker that activates EF hand motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin (CaM), Ca2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia.
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BCC4788
Indapamide
Indapamide is a non-thiazide sulphonamide diuretic compound, generally used in the treatment of hypertension, as well as decompensated cardiac failure.
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BCC6593
Muscimol
Potent GABAA agonist
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BCC7994
CHC
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BCC1119
Bumetanide
Bumetanide (Ro 10-6338;PF 1593) is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
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BCC7617
L-838,417
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BCC5077
Oxcarbazepine
Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM.
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BCC1943
Senicapoc
Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM.
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BCC1122
TRAM-34
TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+ channel (IKCa1) (Kd=20 nM).
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BCC3785
Glipizide
Glipizide(K 4024; CP 2872) is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
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BCC7794
Licarbazepine
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BCC4378
Carbamazepine
Carbamazepine, a sodium channel blocker, is an anticonvulsant drug.
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BCN1749
Hypotaurine
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor.
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BCC7482
TCS 46b
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BCC7008
Ochratoxin A
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BCC1088
Dynasore
Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM.
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BCC4398
Flunarizine 2HCl
Flunarizine is a selective calcium entry blocker.
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BCC6864
Spermine tetrahydrochloride
Spermine tetrahydrochloride is an endogenous metabolite.
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BCC4419
CFTRinh-172
CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM.
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BCC6358
ICA 121431
ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM).
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BCC7764
Reversan
Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor.
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BCC7803
VU 590 dihydrochloride
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BCC7499
PD 118057
PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade.
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BCC7044
VDM 11
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BCC6815
Evans Blue tetrasodium salt
Selective P2X purinergic antagonist,Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
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BCC7266
SCS
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BCC6338
ICA 110381
ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM).
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BCC7720
Indiplon
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BCC4104
GlyH-101
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
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BCC5784
pep2-SVKI
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BCC7816
TCS 5861528
Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).
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BCC6276
ML SA1
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BCC5003
Gliquidone
Gliquidone (AR-DF 26) is an anti-diabetic drug in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
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BCC6865
Spermidine trihydrochloride
Spermidine trihydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine trihydrochloride significantly decreases the H2O2 and O2.- contents.
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BCC7114
6'-Iodoresiniferatoxin
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BCC7930
(S)-(+)-Ketamine hydrochloride
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BCC6909
1-BCP
1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents. 1-BCP is a memory-enhancing agent.
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BCC5079
Propafenone HCl
Propafenone (hydrochloride) (SA-79 (hydrochloride)) is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
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BCC6190
NS 3623
NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels.
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BCC6323
Optovin
Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM).
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BCC4910
HC-030031
HC-030031 is a potent and selective TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2±0.2 and 5.3±0.2 μM, respectively.
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BCC6307
NS 6180
NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.
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BCC7819
TCS 1205
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BCC7546
Valerenic acid
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BCC5497
Brivaracetam
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BCC1803
NNC 55-0396
NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
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BCC6868
Diazoxide
Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
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BCC4074
Icilin
Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.
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BCC6563
ZAPA sulfate
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BCC7748
DS2
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BCC1661
Istaroxime hydrochloride
Istaroxime hydrochloride is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM.
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BCC5377
LY451395
Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
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BCC1725
LY450108
LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator.
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BCC7516
NBMPR
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BCC6205
DQP 1105
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BCC6151
CMPDA
CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor.
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BCC6564
TACA