Membrane Transporter/Ion Channel
Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins)
Products for Membrane Transporter/Ion Channel
- P2X purinergic receptor(31)
- Calcium Channel(77)
- Potassium Channel(80)
- NMDA Receptor(80)
- Sodium Channel(43)
- ATPase(32)
- TRP Channel(44)
- Proton Pump(12)
- AMPAR(49)
- GABA Receptor(103)
- Glycine Transporters(6)
- Chloride Channels(11)
- Glutamate (EAAT) Transporters(19)
- GTPase(7)
- Other Channel Modulators(7)
- CFTR(10)
- Multidrug Transporters(4)
- M2 ion Channel(1)
- Monoamine transporter(4)
- P-gp(6)
- TRPV1(4)
- MCT(2)
- Na+/Ca2+ Exchanger(7)
- Cannabinoid Transporters(7)
- Nucleoside Transporters(3)
- Lipophilic platinum complex(1)
- Monocarboxylate Transporters(1)
- NKCC(2)
- Gardos Channel(1)
- Glycine Receptors(1)
- MCT2(2)
- Glucose Transporters(1)
- ICB(2)
- GlyT1(2)
- Kv1.3(1)
- URAT1(1)
- Cat.No. Product Name Information
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BCC3760
Dibucaine (Cinchocaine) HCl
Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor.
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BCC7373
TNP-ATP triethylammonium salt
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BCC5492
Procainamide HCl
Procainamide hydrochloride is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures.
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BCC6811
DHBP dibromide
DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
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BCC5814
OMDM-2
OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a Ki of 3.0 μM.
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BCC6621
W-5 hydrochloride
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BCC6622
W-7 hydrochloride
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BCC1986
Tariquidar methanesulfonate, hydrate
Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.
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BCC7043
NF 449
Highly selective P2X1 antagonist
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BCC6169
TP 003
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BCC5069
Ouabain
Ouabain is a selective Na+/K+, -ATPase inhibitor, binds to α2 /α3 subunit with Ki of 41 nM/15 nM.
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BCC5071
Phenytoin sodium
Phenytoin sodium is an inactive voltage-gated sodium channel stabilizer.
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BCC6804
(±)-threo-3-Methylglutamic acid
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BCC8024
Rose Bengal
Potent VGlut and VMAT inhibitor; cell permeable
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BCC7140
8-CPT-2Me-cAMP, sodium salt
Selective Epac activator
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BCC4809
Nisoldipine
Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
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BCC4123
(R)-Baclofen hydrochloride
(R)-Baclofen hydrochloride (STX 209 hydrochloride) is a selective GABAB receptor agonist.
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BCC5001
Tolbutamide
Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.
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BCC7234
Ro 04-5595 hydrochloride
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BCC6595
L-trans-2,4-PDC
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BCC5004
Nicorandil
Nicorandil (SG-75) is potassium channel activator.
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BCC1052
AMG-517
AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.
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BCC7914
GW 542573X
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BCC7162
CL 218872
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BCC7391
Talniflumate
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BCC6952
Thapsigargin
Thapsigargin is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin is a well characterized Endoplasmic Reticulum (ER) stress inducing agent.
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BCC7597
Polygodial
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BCC7864
Bepridil hydrochloride
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.
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BCC2512
Zonisamide
Zonisamide is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.
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BCC4240
Zonisamide sodium
Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.
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BCC7388
Nonactin
Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+. Nonactin is able to uncouple the oxidative phosphorylation of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin. Nonactin inhibits the surface expression of endogenous HSP60.
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BCC5918
PPDA
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BCC7543
WS 12
WS-12 is an agonist of TRPM8 with an EC50 of 39 nM.
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BCC2039
Vigabatrin
Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
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BCC6575
Isoguvacine hydrochloride
Isoguvacine hydrochloride is a GABA receptor agonist.
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BCC4503
(R)-baclofen
(R)-Baclofen(STX209) is a selective GABAB receptor agonist.
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BCC7452
17-PA
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BCC6623
W-9 hydrochloride
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BCC6111
TCN 237 dihydrochloride
NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.
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BCC1251
Ivermectin
Ivermectin (MK-933) is a broad-spectrum anti-parasite medication used in humans most commonly to treat nematode infections such as onchocerciasis, as well as scabies and lice. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import.
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BCC1288
(+)-MK 801
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BCC7515
Veratridine
Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM.
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BCC6294
APETx2
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BCC6629
3-Methyl-GABA
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BCC7845
Org 24598 lithium salt
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BCC6867
9-AC
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BCC4219
Aniracetam
Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.
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BCC7927
Psora 4
Potent KV1.3 channel blocker
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BCC7938
STF 31
STF-31 is an inhibitor of glucose transporter 1 (GLUT1, IC50 = 1 μM).
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BCC4402
Felodipine
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker.
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BCC7760
K858
K858 Racemic is an ATP-uncompetitive inhibitor of kinesin Eg5 with an IC50 of 1.3 μM.
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BCC6565
L-(-)-threo-3-Hydroxyaspartic acid
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BCC7526
CyPPA
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BCC5692
SCH 50911
SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM.
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BCC6587
cis-ACBD
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BCC6555
(-)-Bicuculline methobromide
(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons.
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BCC6560
(RS)-AMPA
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BCC2037
Vernakalant Hydrochloride
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. IC50 for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channelwt, Kv1.5 channelI508F, Kv1.5 channelT479A, respectively.
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BCC6943
CGP 37157
CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria, with an IC50 of 0.8 μM.
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BCC4456
Flupirtine maleate
Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.
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BCC3799
Nilvadipine
Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
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BCC3797
Isradipine (Dynacirc)
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.
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BCC7154
SCH 28080
SCH28080 inhibits gastric H+/K+-ATPase by K+-competitive binding, with an IC50 value of 20 nM in rabbit microsomal membranes. Antisecretory and cytoprotective activities.
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BCC6552
DL-AP5
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BCC7717
5-BDBD
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BCC4649
Chlorthalidone
Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
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BCC4014
(+)-MK 801 Maleate
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
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BCC1327
Acamprosate calcium
Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.
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BCC7578
KM 11060
KM11060 is a novel corrector of the F508del-CFTR trafficking defect.
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BCC3881
PTC124 (Ataluren)
Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.
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BCC6070
MRK 016
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BCC7416
PSB 069
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BCC6694
FG 7142
FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex.
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BCC6551
DL-AP7
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BCC6554
L-AP5
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BCC6553
D-AP5
D-AP5 is a NMDA receptor antagonist.
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BCC6625
A-7 hydrochloride
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BCC2036
Vernakalant
Vernakalant(RSD-1235) is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation (AF) in humans at 2 to 5 mg/kg and may be more atrial-selective than available agents; in treatment of antiarrhythmic.
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BCC5859
Norketamine hydrochloride
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BCC1301
20-HETE
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor. 20-HETE is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE constricts smooth muscles, stimulates smooth muscle proliferation and migration. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity. 20-HETE also inhibits endothelial NO synthase and inhibits apoptosis of pulmonary artery smooth muscle cells.
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BCC6671
Dihydroergotoxine mesylate
Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.
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BCC6559
D-AP7
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BCC7668
JNJ 17203212
JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1.
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BCC6325
SN 2
SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.
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BCC6140
A 784168
Potent and selective TRPV1 antagonist
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BCC7105
DCPIB
DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells.
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BCC6583
(S)-AMPA
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BCC6582
(R)-AMPA
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BCC6222
YM 244769
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BCC5051
Lamotrigine
Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channel Target: Sodium Channel Lamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1].
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BCC7711
Bretazenil
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BCC6635
β-CCB
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BCC5896
MNI-caged-D-aspartate
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BCC1419
Bitopertin
Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.
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BCC1420
Bitopertin (R enantiomer)
Bitopertin R enantiomer (RG1678 R enantiomer; RO4917838 R enantiomer) is the R-enantiomer of Bitopertin. Bitopertin is a potent, noncompetitive glycine reuptake inhibitor, inhibits glycine uptake at human GlyT1 with a concentration exhibiting IC50 of 25 nM.
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BCC5970
Lorazepam
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BCC4277
NBI-98782
NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.
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BCC6803
THIP hydrochloride
Gaboxadol hydrochloride (Lu 02-030 hydrochloride; THIP hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). Gaboxadol hydrochloride is a non-opioid analgesic and has hypnotic activities.
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BCC6044
RuBi-4AP
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BCC6122
TCN 201