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Membrane Transporter/Ion Channel

Ion channels are pore-forming membrane proteins whose functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. Ion channels are one of the two classes of ionophoric proteins, along with ion transporters (including the sodium-potassium pump, sodium-calcium exchanger, and sodium-glucose transport proteins)

Products for Membrane Transporter/Ion Channel

Cat.No. Product Name Information
BCC6918 2-Methylthioadenosine triphosphate tetrasodium salt
BCC5690 Camstatin
BCC5239 Lercanidipine Lercanidipine is a calcium channel blocker of the dihydropyridine class.
BCC6904 1-EBIO
BCC6561 (RS)-CPP
BCC7971 Gadolinium chloride
BCC1914 S0859 S0859 is a selective, high-affinity generic NBC inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
BCC7015 PPNDS
BCC7004 ARL 67156 trisodium salt ARL67156 trisodium salt is an inhibitor of ecto-ATPase. ARL 67156 is a weak competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively.
BCC7769 RN 1747 RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM.
BCC5432 Pantoprazole Pantoprazole (BY1023; SKF96022) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.
BCC7548 RO-3
BCC7072 GYKI 52466 dihydrochloride
BCC6012 RuBi-GABA
BCC7445 L-364,373
BCC1058 Lansoprazole Lansoprazole(AG 1749) is a proton pump inhibitor which prevents the stomach from producing acid.
BCC4403 Lacidipine Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.
BCC6997 SR 95531 hydrobromide Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor.
BCC7367 NF 157 NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA).
BCC6985 NF 023
BCC7476 Naspm trihydrochloride Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
BCC6157 Ro 51
BCC7417 PSB 06126
BCC5005 Nateglinide Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].
BCC7288 STEARDA
BCC7138 OLDA
BCC5078 Rufinamide Rufinamide(E 2080; CGP 33101; RUF 331) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).
BCC5700 ω-Conotoxin GVIA
BCN2744 Sarcosine Sarcosine is a glycine transporter type 1 (GlyT) inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site.
BCC6711 NPPB NPPB is a blocker of the outwardly rectifying chloride channel (ORCC).
BCC7303 CGS 9343B Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM. Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
BCC7010 CI 966 hydrochloride
BCC6986 CGS 19755
BCC1770 ML-7 hydrochloride ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM).
BCC7767 Efonidipine hydrochloride monoethanolate Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB).
BCC7067 Ruthenium Red
BCC7404 NF 110
BCC7375 CGS 20625
BCC4397 Amlodipine Besylate Amlodipine besylate is a long-acting calcium channel blocker.
BCC6571 L-Cysteinesulfinic acid L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
BCC7129 Remacemide hydrochloride
BCC6589 (S)-(-)-HA-966
BCC7692 UCPH 101 UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM.
BCC7892 MitMAB
BCC7893 OctMAB
BCC6059 4,4-Pentamethylenepiperidine hydrochloride
BCC6198 A 804598 A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively.
BCC7891 Dynole 34-2
BCC7643 BzATP triethylammonium salt
BCC5946 HU 211 Dexanabinol (HU-211) is an artificially synthesized cannabinoid derivative and lacks cannabimimetic effects. Dexanabinol exhibits not only the antioxidant and neuroprotective activities in brain but also anti-inflammatory activity by inhibiting NF-κB and decreasing cytokines such as TNFα and interleukin-6, which could ensure the integrity of BBB and reduce cell apoptosis and death. Dexanabinol is widely used in head injury or stroke treatment and has been shown to be safe in animals and humans.
BCC7231 Linopirdine dihydrochloride
BCC7309 PPPA
BCC1664 Ivacaftor hydrate Ivacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.
BCC1663 Ivacaftor benzenesulfonate Ivacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.
BCC7115 Tracazolate hydrochloride
BCC7087 CGP 78608 hydrochloride CGP 78608 hydrochloride is a highly potent and selective antagonist at the glycine-binding site of the NMDA receptor, with an IC50 of 6 nM. CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents, with an estimated EC50 in the low nM range (26.3 nM). Anticonvulsant activity.
BCC1682 KN-92 phosphate KN-92 phosphate is an inactive derivative of KN-93.
BCC7182 E-4031 dihydrochloride E-4031 is a class III antiarrhythmic agent which selectively blocks hERG potassium channel.
BCC6089 cis-Ned 19
BCC7308 PMPA (NMDA antagonist)
BCC4373 Golgicide A Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1. Golgicide A drastically reduced replication of coxsackievirus B3 (CVB3) and other human enterovirus species.
BCC6562 Phaclofen
BCC6569 CNQX CNQX (FG9065) is a potent AMPA/kainate receptor antagonist.
BCC6305 8-pCPT-2-O-Me-cAMP-AM
BCC1241 VX-661 Tezacaftor (VX-661) is a second F508del CFTR corrector and help CFTR protein reach the cell surface.
BCC3770 Dofetilide Dofetilide(Tikosyn) is a class III antiarrhythmic agent.
BCC7672 EIPA EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
BCC6244 TC-I 2000
BCC7771 Pyr3 Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx.
BCC7673 Phenamil
BCC1748 Mibefradil Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.
BCC1749 Mibefradil dihydrochloride Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively.
BCC7967 A 967079 A-967079 is a selective TRPA1 receptor antagonist with IC50s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and has good penetration into the CNS.
BCC7112 STO-609 acetate
BCC6579 2-Hydroxysaclofen
BCC6999 D-CPP-ene
BCC4160 Felbamate hydrate Felbamate hydrate (W-554 hydrate) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .
BCC7292 N20C hydrochloride
BCC6050 Enterostatin Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.
BCC7009 Loreclezole hydrochloride Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
BCC6608 L-CCG-lll
BCC6013 GLYX 13 Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist.
BCC5228 Rabeprazole Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.
BCC5227 Rabeprazole sodium Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in the class of proton pump inhibitors.
BCC7758 5,7-Dichlorokynurenic acid sodium salt
BCC6624 NBQX NBQX is a highly selective and competitive AMPA receptor antagonist.
BCC7507 Fumitremorgin C Fumitremorgin C is a potent and selective ABCG2/BRCP inhibitor.
BCC1726 M2 ion channel blocker M2 ion channel blocker is capable of inhibiting and blocking the activity of M2 ion channel;Antiviral agent.
BCC3922 IOWH-032 IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays.
BCC7280 Eliprodil Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).
BCC1959 Sodium Channel inhibitor 1 Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment.
BCC5430 Esomeprazole magnesium salt Esomeprazole magnesium salt is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
BCC5412 Mofegiline hydrochloride Mofegiline hydrochloride (MDL72974A) is a potent and selective enzyme-activated irreversible inhibitor of MAO-B; shows marked selectivity for the B form (IC50 = 680 and 3.6 nM for MAO-A and MAO-B).
BCC7050 FPL 64176
BCC7135 IEM 1460
BCC6179 TC-N 1752
BCC7181 SR 33805 oxalate
BCC7454 POM 1 Sodium metatungstate (POM-1) is a potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with Ki values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1, NTPDase 3 and NTPDase 2 respectively. Sodium metatungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.
BCC7560 DMCM hydrochloride DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively.
BCC7227 ZK 93423 hydrochloride Potent benzodiazepine agonist